ArticleBrain and behavior2017
Relationships between cardiorespiratory fitness, hippocampal volume, and episodic memory in a population at risk for Alzheimer's disease.
Open access · goldAbstract read
In one paragraph
Article in Brain and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Alzheimer's disease large-scale gene expression portrait identifies exercise as the top theoretical treatment.Scientific reports · 2022Pooled it
- [Effect of physical exercise on Alzheimer's disease. A sistematic review].Atencion primaria · 2020Pooled it
- The Association of Cardiorespiratory Fitness on Memory Function: Systematic Review.Medicina (Kaunas, Lithuania) · 2019Pooled it
- Effect of a 24-week resistance exercise intervention on cognitive function in cognitively normal older adults: The AGUEDA randomized controlled trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Trial
- A new set of estimated cardiorespiratory fitness equations are associated with cognitive performance in older adults.GeroScience · 2023Trial
- Sex differentials in relationships between functional fitness and cognitive performance in older adults: a canonical correlation analysis.Scientific reports · 2018Trial
- Associations of cardiorespiratory fitness with structural brain networks in ageing: insights from The Maastricht Study.GeroScience · 2026Article
- Rising energetic cost of walking predicts cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Cardiorespiratory fitness and cardiometabolic health are associated with distinct cognitive domains in cognitively healthy older adults.Scientific reports · 2025Article
- Association among cardiorespiratory fitness, plasma biomarkers of pathology and astrocyte reactivity, and cognition in autosomal-dominant Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2025Article
- Cardiorespiratory fitness is associated with cognitive function in late adulthood: baseline findings from the IGNITE study.British journal of sports medicine · 2025Article
- Alzheimer's Disease: Understanding Motor Impairments.Brain sciences · 2024Review
- Cardiorespiratory fitness, hippocampal subfield morphology, and episodic memory in older adults.Frontiers in aging neuroscience · 2024Article
- Exercise and Protection from Age-Related Cognitive Decline.Current topics in behavioral neurosciences · 2024Review
- The association between cardiovascular health and cognition in adults with Down syndrome.Journal of neurodevelopmental disorders · 2023Article
- Implications of Physical Exercise on Episodic Memory and Anxiety: The Role of the Serotonergic System.International journal of molecular sciences · 2023Review
- Exercise as therapy for neurodevelopmental and cognitive dysfunction in people with a Fontan circulation: A narrative review.Frontiers in pediatrics · 2023Review
- Insulin Homeostasis Mediates the Relationship Between Cardiorespiratory Fitness and Cognitive Speed in Aging Adults.Journal of Alzheimer's disease : JAD · 2023Observational
- Energetic Cost of Walking and Brain Atrophy in Mid-to-Late Life.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Five-year changes in objectively measured cardiorespiratory fitness, physical activity, and sedentary time in mid-to-late adulthood.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 5 institutions in 1 country.
Ryan J DoughertyWilliam S. Middleton Memorial Veterans Hospital Madison WI USA; Department of Kinesiology University of Wisconsin School of Education Madison WI USA.
Stephanie A SchultzGeriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison WI USA; Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA; Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA.
Elizabeth A BootsDepartment of Kinesiology University of Wisconsin School of Education Madison WI USA; Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA; Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA.
Laura D EllingsonWilliam S. Middleton Memorial Veterans Hospital Madison WI USA; Department of Kinesiology Iowa State University College of Human Sciences Ames IA USA.
Jacob D MeyerWilliam S. Middleton Memorial Veterans Hospital Madison WI USA; Department of Family Medicine and Community Health University of Wisconsin Madison WI USA.
Stephanie Van RiperWilliam S. Middleton Memorial Veterans Hospital Madison WI USA; Geriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison WI USA.
Aaron J StegnerWilliam S. Middleton Memorial Veterans Hospital Madison WI USA; Geriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison WI USA.
Dorothy F EdwardsGeriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison WI USA; Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA; Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA.
Jennifer M OhDepartment of Kinesiology University of Wisconsin School of Education Madison WI USA; Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA; Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA.
Jean EinersonDivision of Cardiology University of Wisconsin School of Medicine and Public Health Madison WI USA.
Claudia E KorcarzDivision of Cardiology University of Wisconsin School of Medicine and Public Health Madison WI USA.
Rebecca L KoscikWisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA.
Maritza N DowlingDepartment of Biostatistics & Medical Informatics University of Wisconsin School of Medicine and Public Health Madison WI USA.
Catherine L GallagherDepartment of Kinesiology University of Wisconsin School of Education Madison WI USA; Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA.
Cynthia M CarlssonDepartment of Kinesiology University of Wisconsin School of Education Madison WI USA; Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA.
Howard A RowleyGeriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison WI USA.
Barbara B BendlinDepartment of Kinesiology University of Wisconsin School of Education Madison WI USA; Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA; Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA.
Sanjay AsthanaDepartment of Kinesiology University of Wisconsin School of Education Madison WI USA; Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA.
Bruce P HermannWisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA; Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA; Department of Neurology University of Wisconsin School of Medicine and Public Health Madison WI USA.
Mark A SagerWisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA; Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA.
James H SteinDivision of Cardiology University of Wisconsin School of Medicine and Public Health Madison WI USA.
Sterling C JohnsonDepartment of Kinesiology University of Wisconsin School of Education Madison WI USA; Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA; Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA.
Ozioma C OkonkwoDepartment of Kinesiology University of Wisconsin School of Education Madison WI USA; Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA; Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA.
Dane B CookWilliam S. Middleton Memorial Veterans Hospital Madison WI USA; Geriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison WI USA.
University of Wisconsin–Madison · USWilliam S. Middleton Memorial Veterans Hospital · USWisconsin Division of Public Health · USGeriatric Research Education and Clinical Center · USIowa State University · US
Funding
Wisconsin Registry for Alzheimer's Prevention: Sex Differences in DNA MethylationR01AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Nathaniel Ark Chin, Sterling C Johnson · 2007 to 2026
$35.6MInstitutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2MINSTITUTIONAL CTSA (UW-MADISON): CLINICAL TRIALSUL1RR025011 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2007 to 2011
$29.5MThe Longitudinal Course of Neural Function and Amyloid in People At Risk for ADR01AG021155 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sterling C Johnson · 2004 to 2026
$27.0MWisconsin Alzheimer's Disease Research CenterP50AG033514 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI ASTHANA, SANJAY · 2009 to 2018
$16.2MStatin Effects on Beta-Amyloid and Cerebral Perfusion in Adults at Risk for ADR01AG031790 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CARLSSON, CYNTHIA M · 2009 to 2013
$1.6MEarly detection of asymptomatic middle-age adults at risk for ADK23AG045957 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI OKONKWO, OZIOMA C · 2013 to 2017
$884kWhite matter degeneration: biomarkers in preclinical Alzheimer's DiseaseR56AG037639 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI BENDLIN, BARBARA BRIGITTA · 2017 to 2017
$759kNCATS NIH HHS UL1 TR000427NCRR NIH HHS UL1 RR025011NIA NIH HHS K23 AG045957NIA NIH HHS P50 AG033514NIA NIH HHS R01 AG021155NIA NIH HHS R01 AG027161NIA NIH HHS R01 AG031790NIA NIH HHS R56 AG037639
Abstract
introductionCardiorespiratory fitness (CRF) has been shown to be related to brain health in older adults. In individuals at risk for developing Alzheimer's disease (AD), CRF may be a modifiable risk factor that could attenuate anticipated declines in brain volume and episodic memory. The objective of this study was to determine the association between CRF and both hippocampal volume and episodic memory in a cohort of cognitively healthy older adults with familial and/or genetic risk for Alzheimer's disease (AD).
methodsEighty-six enrollees from the Wisconsin Registry for Alzheimer's Prevention participated in this study. Participants performed a graded maximal exercise test, underwent a T-1 anatomical magnetic resonance imaging scan, and completed the Rey Auditory Verbal Learning Test (RAVLT).
resultsThere were no significant relationships between CRF and HV or RAVLT memory scores for the entire sample. When the sample was explored on the basis of gender, CRF was significantly associated with hippocampal volume for women. For men, significant positive associations were observed between CRF and RAVLT memory scores. SUMMARY: These results suggest that CRF may be protective against both hippocampal volume and episodic memory decline in older adults at risk for AD, but that the relationships may be gender specific.
Indexed as
Memory, EpisodicRegistriesAgedAlzheimer DiseaseCardiorespiratory FitnessFemaleHippocampusHumansMagnetic Resonance ImagingMaleMiddle AgedProtective FactorsSex FactorsAPOE‐e4cognitionexercisefamily historyphysical activity
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.