Evidence map›Paper›PMID 28293415›Full record

ReviewClinical and translational allergy2017

Approach to the diagnosis of drug hypersensitivity reactions: similarities and differences between Europe and North America.

M J Torres, A Romano, G Celik, P Demoly, D A Khan, E Macy, M Park, K Blumenthal, W Aberer, M Castells and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Clinical and translational allergy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 100 citations in OpenAlex.

  1. Article
  2. Article
  3. Updates in Pediatric Drug Allergy.Current allergy and asthma reports · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Penicillin Allergy Testing Is Cost-Saving: An Economic Evaluation Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Pediatric Drug Hypersensitivity.Current allergy and asthma reports · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 6 countries.

M J TorresAllergy Unit, National Network ARADyAL, IBIMA-Regional University Hospital of Malaga-UMA (Pavilion C), Plaza del Hospital Civil, 29009 Malaga, Spain.
A RomanoAllergy Unit, Presidio Columbus, Rome, Italy.
G CelikDepartment of Chest Diseases, Division of Immunology and Allergy, Ankara University School of Medicine, Ankara, Turkey.
P DemolyHôpital Arnaud de Villeneuve, University Hospital of Montpellier and Sorbonne Universités, UPMC Paris 06, UMR-S 1136, IPLESP, Equipe EPAR, 75013 Paris, France.
D A KhanDepartment of Internal Medicine, Division of Allergy and Immunology, University of Texas Southwestern Medical Center, Dallas, TX USA.
E MacyKaiser Permanente Health Care Program, San Diego, CA USA.
M ParkMayo Clinic College of Medicine, Division of Allergic Diseases, Mayo Clinic, Rochester, MN 55905 USA.
K BlumenthalDivision of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA.
W AbererDepartment of Dermatology, Medical University of Graz, Graz, Austria.
M CastellsDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MSA USA.
A BarbaudSorbonne Universities, UPMC Univ Paris 06, Dermatology and Allergology Department, Tenon Hospital (AP-HP), 4 rue de la chine, 75020 Paris, France.
C Mayorga *Allergy Unit, IBIMA-Regional University Hospital of Malaga-UMA (Pavilion C), Plaza del Hospital Civil, 29009 Malaga, Spain.
P Bonadonna *Allergy Unit, Azienda Ospedaliera Universitaria Intergrata of Verona, Verona, Italy.
Hospital Regional Universitario de Málaga · ESSorbonne Université · FRAnkara University · TRAzienda Ospedaliera Universitaria Integrata Verona · ITBrigham and Women's Hospital · USHarvard University · USKaiser Permanente · USMayo Clinic · USMedical University of Graz · ATOasi Maria SS · ITThe University of Texas Southwestern Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug hypersensitivity reactions (DHRs) affect an unknown proportion of the general population, and are an important public health problem due to their potential to cause life-threatening anaphylaxis and rare severe cutaneous allergic reactions. DHR evaluations are frequently needed in both ambulatory and hospital settings and have a complex diagnosis that requires a detailed clinical history and other tests that may include in vitro tests and in vivo procedures such as skin tests and drug provocation tests. Although over the years both European and U.S. experts have published statements on general procedures for evaluating DHRs, a substantial discordance in their daily management exists. In this review, we highlight both the differences and the similarities between the European and U.S. PERSPECTIVES: While a general consensus exists on the importance of skin tests for evaluating DHRs, concordance between Americans and Europeans exists solely regarding their use in immediate reactions and the fact that a confirmation of a presumptive diagnosis by drug provocation tests is often the only reliable way to establish a diagnosis. Finally, great heterogeneity exists in the application of in vitro tests, which require further study to be well validated.

Indexed as

AllergyDiagnosisDrugDrug provocation testEuropeHypersensitivityIgEIn vitro testSensitizationSkin testT-cellsUnited States

Identifiers

PMID28293415
PMCPMC5347172
OpenAlexW2597233172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.