ArticleIranian journal of basic medical sciences2017
Exploring the effect of intravenous lipid emulsion in acute methamphetamine toxicity.
Article in Iranian journal of basic medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Protective effects of alpha-lipoic acid on anxiety-like behavior, memory and prevention of hippocampal oxidative stress in methamphetamine-treated rats.Psychopharmacology · 2024Article
- Aerobic training and vitamin E administration ameliorates cardiac apoptosis markers in rats exposed to methamphetamine.European journal of translational myology · 2023Article
- A review of basic to clinical studies of the association between hyperammonemia, methamphetamine.Naunyn-Schmiedeberg's archives of pharmacology · 2022Review
- Use of intravenous lipid emulsion therapy as a novel treatment for brevetoxicosis in sea turtles.Scientific reports · 2021Article
- Thymoquinone abrogates methamphetamine-induced striatal neurotoxicity and hyperlocomotor activity in mice.Research in pharmaceutical sciences · 2021Article
- Vitamin B12 and estradiol benzoate improve memory retrieval through activation of the hippocampal AKT, BDNF, and CREB proteins in a rat model of multiple sclerosis.Iranian journal of basic medical sciences · 2021Article
- Protective Effect of Cinnamaldehyde on METH-induced Neurotoxicity in PC12 Cells via Inhibition of Apoptotic Response and Oxidative Stress.Iranian journal of pharmaceutical research : IJPR · 2021Article
- Successful Medical Management of Methamphetamine Induced Ileus; A Rare Case Report and Literature Review.Bulletin of emergency and trauma · 2019Article
- Cinnamaldehyde improves methamphetamine-induced spatial learning and memory deficits and restores ERK signaling in the rat prefrontal cortex.Iranian journal of basic medical sciences · 2018Article
- The effects of vitamin BIranian journal of basic medical sciences · 2018Article
- Role of natural products in mitigation of toxic effects of methamphetamine: A review ofAvicenna journal of phytomedicineReview
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe increasing use of methamphetamine (METH) in the last decades has made it the second most abused drug. Advancs in the area of intravenous lipid emulsion (ILE) have led to its potential application in the treatment of poisoning. The present study aims to investigate the potential role of ILE as an antidote for acute METH poisoning. MATERIALS AND
methodsTwo groups of six male rats were treated by METH (45 mg/kg), intraperitoneally. Five to seven min later, they received an infusion of 18.6 ml/kg ILE 20% through the tail vein or normal saline (NS). Locomotor and behavioral activity was assessed at different time after METH administration. Body temperature and survival rates were also evaluated. Brain and internal organs were then removed for histological examination and TUNEL assay.
resultsILE therapy for METH poisoning in rats could prevent rats mortalities and returned the METH-induced hyperthermia to normal rates (
conclusionILE could reduce the severity of METH- induced toxicity as well as mortality rate in the animals. Intravenous infusion of lipid emulsion may save the life of patients with acute METH intoxication who do not respond to standard initial therapy.
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