ArticleFrontiers in human neuroscience2017
Hypoconnectivity of Resting-State Networks in Persons with Aphasia Compared with Healthy Age-Matched Adults.
Article in Frontiers in human neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- The changed functional status of the brain was involved in patients with poststroke aphasia: Coordinate-based (activation likelihood estimation) meta-analysis.Brain and behavior · 2020Pooled it
- fNIRS-Guided neuronavigated rTMS augments naming recovery in subacute post-stroke aphasia: a double-blind randomized controlled trial.Frontiers in human neuroscience · 2026Trial
- Effects of a Tablet-Based Home Practice Program With Telepractice on Treatment Outcomes in Chronic Aphasia.Journal of speech, language, and hearing research : JSLHR · 2018Trial
- Right Hemisphere Functional Connectivity Increases in Proportion to Left Hemisphere Lesion Size, but Not Within the Language Network.Human brain mapping · 2026Observational
- Test-retest reliability of edge-level resting-state functional connectivity in people with aphasia.Neuroimage. Reports · 2025Article
- Cerebello-Cerebral Resting-State Functional Connectivity in Poststroke Aphasia.Brain connectivity · 2025Article
- Defining Trajectories of Linguistic, Cognitive-Communicative, and Quality of Life Outcomes in Aphasia: Longitudinal Observational Study Protocol.Archives of rehabilitation research and clinical translation · 2024Article
- Resting-state brain network connectivity is an independent predictor of responsiveness to language therapy in chronic post-stroke aphasia.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Disentangling neuroplasticity mechanisms in post-stroke language recovery.Brain and language · 2024Review
- Insights gained over 60 years on factors shaping post-stroke aphasia recovery: A commentary on Vignolo (1964).Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Altered Spontaneous Brain Activity in Poststroke Aphasia: A Resting-State fMRI Study.Brain sciences · 2023Article
- Review
- Targeted neurorehabilitation strategies in post-stroke aphasia.Restorative neurology and neuroscience · 2023Review
- Dissociable language and executive control deficits and recovery in post-stroke aphasia: An exploratory observational and case series study.Neuropsychologia · 2022Observational
- Structural Integrity and Functional Neural Activity Associated with Oral Language Function after Stroke.Journal of clinical medicine · 2022Article
- Predictors of Therapy Response in Chronic Aphasia: Building a Foundation for Personalized Aphasia Therapy.Journal of stroke · 2022Review
- Plasticity of the language system in children and adults.Handbook of clinical neurology · 2022Review
- Understanding Language Reorganization With Neuroimaging: How Language Adapts to Different Focal Lesions and Insights Into Clinical Applications.Frontiers in human neuroscience · 2022Review
- The Unfolding of Cognitive Effort During Sentence Processing: Pupillometric Evidence From People With and Without Aphasia.Journal of speech, language, and hearing research : JSLHR · 2021Article
- Abnormally weak functional connections get stronger in chronic stroke patients who benefit from naming therapy.Brain and language · 2021Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Aphasia is a language disorder affecting more than one million people in the US. While language function has traditionally been the focus of neuroimaging research, other cognitive functions are affected in this population, which has implications not only for those specific processes but also for the interaction of language and other cognitive functions. Resting state fMRI (rs-fMRI) is a practical and informative way to explore and characterize general cognitive engagement and/or health in this population, but it is currently underutilized. The aim of this study was to explore the functional connectivity in resting state networks (RSNs) and in the semantic network in seven persons with aphasia (PWA) who were at least 6 months post onset compared with 11 neurologically healthy adults (NHA) in order to gain a more comprehensive understanding of general cognitive engagement in aphasia. These preliminary results show that PWA exhibit hypoconnectivity in the semantic network and all RSNs except the visual network. Compared with NHA, PWA appear to have fewer cross- and left-hemispheric connections. However, PWA exhibit some stronger connections than NHA within the semantic network, which could indicate compensatory mechanisms. Importantly, connectivity for RSNs appear to increase with decreasing aphasia severity and decrease with increasing lesion size. This knowledge has the potential to improve aphasia therapy by furthering the understanding of lesion effects on the cognitive system as a whole, which can guide treatment target selection and promotion of favorable neural reorganization for optimal recovery of function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.