Evidence map›Paper›PMID 28293119›Full record

ReviewBreast cancer (Dove Medical Press)2017

Intensity modulated radiation therapy for breast cancer: current perspectives.

Milly Buwenge, Silvia Cammelli, Ilario Ammendolia, Giorgio Tolento, Alice Zamagni, Alessandra Arcelli, Gabriella Macchia, Francesco Deodato, Savino Cilla, Alessio G Morganti

Abstract readReview
In one paragraph

Review in Breast cancer (Dove Medical Press), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Is prone free breathing better than supine deep inspiration breath-hold for left whole-breast radiotherapy? A dosimetric analysis.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2021
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  5. Personalized Radiation Therapy for Breast Cancer.Current oncology (Toronto, Ont.) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Milly BuwengeDepartment of Experimental, Diagnostic and Specialty Medicine - DIMES, Radiation Oncology Center, University of Bologna, S.Orsola-Malpighi Hospital.
Silvia CammelliDepartment of Experimental, Diagnostic and Specialty Medicine - DIMES, Radiation Oncology Center, University of Bologna, S.Orsola-Malpighi Hospital.
Ilario AmmendoliaDepartment of Experimental, Diagnostic and Specialty Medicine - DIMES, Radiation Oncology Center, University of Bologna, S.Orsola-Malpighi Hospital.
Giorgio TolentoDepartment of Experimental, Diagnostic and Specialty Medicine - DIMES, Radiation Oncology Center, University of Bologna, S.Orsola-Malpighi Hospital.
Alice ZamagniDepartment of Experimental, Diagnostic and Specialty Medicine - DIMES, Radiation Oncology Center, University of Bologna, S.Orsola-Malpighi Hospital.
Alessandra ArcelliRadiation Oncology Unit, Bellaria Hospital, Bologna.
Gabriella MacchiaRadiation Oncology Unit.
Francesco DeodatoRadiation Oncology Unit.
Savino CillaMedical Physics Unit, Research and Care Foundation 'Giovanni Paolo II,' Catholic University of Sacred Heart, Campobasso, Italy.
Alessio G MorgantiDepartment of Experimental, Diagnostic and Specialty Medicine - DIMES, Radiation Oncology Center, University of Bologna, S.Orsola-Malpighi Hospital.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOwing to highly conformed dose distribution, intensity modulated radiation therapy (IMRT) has the potential to improve treatment results of radiotherapy (RT). Postoperative RT is a standard adjuvant treatment in conservative treatment of breast cancer (BC). The aim of this review is to analyze available evidence from randomized controlled trials (RCTs) on IMRT in BC, particularly in terms of reduction of side effects.

methodsA literature search of the bibliographic database PubMed, from January 1990 through November 2016, was performed. Only RCTs published in English were included.

resultsTen articles reporting data from 5 RCTs fulfilled the selection criteria and were included in our review. Three out of 5 studies enrolled only selected patients in terms of increased risk of toxicity. Three studies compared IMRT with standard tangential RT. One study compared the results of IMRT in the supine versus the prone position, and one study compared standard treatment with accelerated partial breast IMRT. Three studies reported reduced acute and/or late toxicity using IMRT compared with standard RT. No study reported improved quality of life.

conclusionIMRT seems able to reduce toxicity in selected patients treated with postoperative RT for BC. Further analyses are needed to better define patients who are candidates for this treatment modality.

Indexed as

breast cancerintensity modulated radiation therapyliterature review

Identifiers

PMID28293119
PMCPMC5345691

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.