Evidence map›Paper›PMID 28292983›Full record

ReviewmBio2017

Origins of Combination Therapy for Tuberculosis: Lessons for Future Antimicrobial Development and Application.

Christopher A Kerantzas, William R Jacobs

Abstract readHistorical ArticleReview
In one paragraph

Review in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Dual inhibition of respiratory complexes inMicrobiology spectrum · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. bioRxiv : the preprint server for biology · 2026
    Article
  11. Review
  12. Review
  13. Bacterial cell envelope-targeting antibiotics.Nature reviews. Microbiology · 2026
    Review
  14. Article
  15. Review
  16. Deconvoluting drug interactions usingAntimicrobial agents and chemotherapy · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Article

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christopher A KerantzasDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
William R JacobsDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA jacobsw@hhmi.org.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6M
Molecular Genetic Analysis of Mycobacterium TuberculosisR37AI026170 · NIAID · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI WILLIAM Robert JACOBS · 2004 to 2026
$7.7M
MOLECULAR GENETIC ANALYSIS OF MYCOBACTERIUM TUBERCULOSISR01AI026170 · NIAID · YESHIVA UNIVERSITY · PI JACOBS, WILLIAM ROBERT · 1989 to 2022
$7.1M
Drugs targeting persistent Mycobacterium TuberculosisR01AI097548 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JACOBS, WILLIAM ROBERT · 2013 to 2016
$2.6M
NIAID NIH HHS R01 AI026170NIAID NIH HHS R01 AI097548NIAID NIH HHS R37 AI026170NIGMS NIH HHS T32 GM007288
6 · The paper itself

Abstract

Tuberculosis is a global health problem that causes the death of approximately 1.5 million people worldwide each year (WHO, p. 1-126,

Indexed as

Aminosalicylic AcidAntitubercular AgentsDrug DiscoveryDrug Therapy, CombinationHistory, 20th CenturyHistory, 21st CenturyHumansStreptomycinTuberculosisUnited KingdomAminosalicylic AcidAntitubercular AgentsStreptomycin

Identifiers

PMID28292983
PMCPMC5350467

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.