Evidence map›Paper›PMID 28292982›Full record

ArticlemBio2017

Antibiotic Capture by Bacterial Lipocalins Uncovers an Extracellular Mechanism of Intrinsic Antibiotic Resistance.

Omar M El-Halfawy, Javier Klett, Rebecca J Ingram, Slade A Loutet, Michael E P Murphy, Sonsoles Martín-Santamaría, Miguel A Valvano

Open access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 39 citations in OpenAlex.

  1. Reverse vaccinology for development of vaccine against Aeromonas hydrophila infection in nile tilapia (Oreochromis niloticus).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
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  3. Akkermansia muciniphila MucNature communications · 2025
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  4. Dark Matter Carried byInternational journal of molecular sciences · 2025
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  5. Review
  6. Article
  7. PredictingMicroorganisms · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. AMicroorganisms · 2021
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Omar M El-HalfawyDepartment of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada.
Javier KlettDepartment of Chemical and Physical Biology, Centre for Biological Research, CIB, CSIC, Madrid, Spain.
Rebecca J IngramThe Wellcome-Wolfson Institute of Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.
Slade A LoutetDepartment of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
Michael E P MurphyDepartment of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
Sonsoles Martín-SantamaríaDepartment of Chemical and Physical Biology, Centre for Biological Research, CIB, CSIC, Madrid, Spain.
Miguel A ValvanoDepartment of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada m.valvano@qub.ac.uk.ORCID 0000-0001-8229-3641
Centro de Investigaciones Biológicas Margarita Salas · ESUniversity of British Columbia · CAWestern University · CAQueen's University Belfast · GB

Funding

CIHR MOP-49597
6 · The paper itself

Abstract

The potential for microbes to overcome antibiotics of different classes before they reach bacterial cells is largely unexplored. Here we show that a soluble bacterial lipocalin produced by

Indexed as

Drug Resistance, BacterialAnti-Bacterial AgentsBurkholderia cenocepaciaGene ExpressionLipocalinsMethicillin-Resistant Staphylococcus aureusMycobacterium tuberculosisPseudomonas aeruginosaAnti-Bacterial AgentsLipocalins

Identifiers

PMID28292982
PMCPMC5350466
OpenAlexW2597347612

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.