Evidence map›Paper›PMID 28292919›Full record

ArticleGenetics2017

Molecular Determinants of the Regulation of Development and Metabolism by Neuronal eIF2α Phosphorylation in

Warakorn Kulalert, Harini Sadeeshkumar, Ying K Zhang, Frank C Schroeder, Dennis H Kim

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Ascaroside Pheromones: Chemical Biology and Pleiotropic Neuronal Functions.International journal of molecular sciences · 2019
    Review
  10. Review
  11. Loss ofmicroPublication biology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Warakorn KulalertDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Harini SadeeshkumarDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Ying K ZhangBoyce Thompson Institute, Cornell University, Ithaca, New York 14853.
Frank C SchroederBoyce Thompson Institute, Cornell University, Ithaca, New York 14853.
Dennis H KimDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 dhkim@mit.edu.
Massachusetts Institute of Technology · USCornell University · US

Funding

CHEMISTRY OF BIOLOGICAL SYSTEMST32GM008500 · NIGMS · CORNELL UNIVERSITY ITHACA · PI LIN, HENING · 1996 to 2020
$5.4M
Molecular Genetics of Innate Immunity in C. elegansR01GM084477 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI KIM, DENNIS H · 2007 to 2020
$4.6M
Small Molecule Signaling in Caenorhabditis elegansR01GM088290 · NIGMS · BOYCE THOMPSON INST FOR PLANT RESEARCH · PI SCHROEDER, FRANK CLEMENS · 2010 to 2017
$2.2M
NIGMS NIH HHS R01 GM084477NIGMS NIH HHS R01 GM088290NIGMS NIH HHS T32 GM008500
6 · The paper itself

Abstract

Cell-nonautonomous effects of signaling in the nervous system of animals can influence diverse aspects of organismal physiology. We previously showed that phosphorylation of Ser49 of the α-subunit of eukaryotic translation initiation factor 2 (eIF2α) in two chemosensory neurons by PEK-1/PERK promotes entry of

Indexed as

Protein BiosynthesisAnimalsBinding SitesCaenorhabditis elegansEukaryotic Initiation Factor-2Eukaryotic Initiation Factor-2BMutationPhosphorylationSensory Receptor CellsEukaryotic Initiation Factor-2Eukaryotic Initiation Factor-2BCaenorhabditis elegansdauereIF2αphosphorylationsensory neuronstranslational control

Identifiers

PMID28292919
PMCPMC5419473
OpenAlexW2601972539

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.