Evidence map›Paper›PMID 28292918›Full record

ArticleGenetics2017

Nonhomologous End-Joining with Minimal Sequence Loss Is Promoted by the Mre11-Rad50-Nbs1-Ctp1 Complex in

Yanhui Li, Jinyu Wang, Gang Zhou, Michael Lajeunesse, Nga Le, Brittany N Stawicki, Yalitza Lopez Corcino, Kathleen L Berkner, Kurt W Runge

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. DNA Repair in Haploid Context.International journal of molecular sciences · 2021
    Review
  7. Review
  8. Review
  9. Article
  10. MRN complex is an essential effector of DNA damage repair.Journal of Zhejiang University. Science. B · 2021
    Review
  11. Genes · 2020
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Yanhui LiDepartment of Molecular Genetics.
Jinyu WangDepartment of Molecular Genetics.
Gang ZhouCellular and Molecular Medicine, and.
Michael LajeunesseDepartment of Biology, John Carroll University, University Heights, OH 44118.
Nga LeBiomedical Sciences Training Program, Case Western Reserve University School of Medicine, Cleveland, Ohio, 44106, and.
Brittany N StawickiBiomedical Sciences Training Program, Case Western Reserve University School of Medicine, Cleveland, Ohio, 44106, and.
Yalitza Lopez CorcinoBiomedical Sciences Training Program, Case Western Reserve University School of Medicine, Cleveland, Ohio, 44106, and.
Kathleen L BerknerDepartment of Genetics and Genomic Sciences, and.
Kurt W RungeDepartment of Molecular Genetics, rungek@ccf.org.ORCID 0000-0001-8492-0530
Pediatrics and Genetics · USUniversity School · USCase Western Reserve University · USCleveland Clinic Lerner College of Medicine · USJohn Carroll University · US

Funding

STRUCTURE/FUNCTION ANALYSIS OF THE GAMMA-CARBOXYLASER01HL055666 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BERKNER, KATHLEEN LUCILE · 1997 to 2017
$5.4M
Vitamin K Oxidoreductase: Function and PhysiologyR01HL081093 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BERKNER, KATHLEEN LUCILE · 2008 to 2017
$3.4M
REGULATION OF TELOMERE LENGTHR01GM050752 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI RUNGE, KURT W · 1994 to 2012
$3.2M
Control of Yeast Life SpanR01AG019960 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI RUNGE, KURT W · 2001 to 2014
$3.2M
Regulation of lifespanR01AG051601 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI RUNGE, KURT W · 2016 to 2020
$1.6M
NHLBI NIH HHS R01 HL055666NHLBI NIH HHS R01 HL081093NIA NIH HHS R01 AG019960NIA NIH HHS R01 AG051601NIGMS NIH HHS R01 GM050752
6 · The paper itself

Abstract

While the Mre11-Rad50-Nbs1 (MRN) complex has known roles in repair processes like homologous recombination and microhomology-mediated end-joining, its role in nonhomologous end-joining (NHEJ) is unclear as

Indexed as

Chromosomal Proteins, Non-HistoneDNADNA-Binding ProteinsDNA Breaks, Double-StrandedDNA End-Joining RepairEndodeoxyribonucleasesExodeoxyribonucleasesMultiprotein ComplexesSchizosaccharomycesSchizosaccharomyces pombe ProteinsChromosomal Proteins, Non-HistoneCtp1 protein, S pombeDNADNA-Binding ProteinsEndodeoxyribonucleasesExodeoxyribonucleasesMre11 protein, S pombeMultiprotein ComplexesNbs1 protein, S pombePso2 protein, S pombeRad50 protein, S pombeSchizosaccharomyces pombe ProteinshairpinhATHermesMre11-Rad50-Nbs1Mre11-Rad50-Xrs2MRNMRXNHEJnonhomologous end-joiningtransposon

Identifiers

PMID28292918
PMCPMC5419490
OpenAlexW2610301822

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.