Evidence map›Paper›PMID 28292827›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

The Glycoside Oleandrin Reduces Glioma Growth with Direct and Indirect Effects on Tumor Cells.

Stefano Garofalo, Alfonso Grimaldi, Giuseppina Chece, Alessandra Porzia, Stefania Morrone, Fabrizio Mainiero, Giuseppina D'Alessandro, Vincenzo Esposito, Barbara Cortese, Silvia Di Angelantonio and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. NaFrontiers in chemistry · 2026
    Article
  3. Article
  4. The Small Molecules of Plant Origin with Anti-Glioma Activity.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Review
  7. PBI-05204, a supercritical CONeoplasia (New York, N.Y.) · 2024
    Article
  8. Review
  9. Review
  10. Molecular Modes of Action of an AqueousMolecules (Basel, Switzerland) · 2023
    Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Antiviral Effects of Oleandrin.Journal of experimental pharmacology · 2020
    Review
  16. The Botanical Drug PBI-05204, a Supercritical COFrontiers in pharmacology · 2020
    Article
  17. TET1 regulates DNA repair in human glial cells.Toxicology and applied pharmacology · 2019
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Stefano GarofaloDepartment of Physiology and Pharmacology.
Alfonso GrimaldiDepartment of Physiology and Pharmacology.
Giuseppina CheceDepartment of Physiology and Pharmacology.
Alessandra PorziaIstituto di Ricovero e Cura a Carattere Scientifico, Neuromed, 86077 Pozzilli, Italy.
Stefania MorroneDepartment of Experimental Medicine.
Fabrizio MainieroDepartment of Experimental Medicine.ORCID 0000-0002-7136-9839
Giuseppina D'AlessandroDepartment of Physiology and Pharmacology.
Vincenzo EspositoIstituto di Ricovero e Cura a Carattere Scientifico, Neuromed, 86077 Pozzilli, Italy.
Barbara CorteseConsiglio Nazionale delle Ricerche-Nanotec, Institute of Nanotechnology, Soft and Living Matter Laboratory, Department of Physics.ORCID 0000-0001-8667-7255
Silvia Di AngelantonioDepartment of Physiology and Pharmacology.
Flavia TrettelDepartment of Physiology and Pharmacology, Laboratory Affiliated with Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University, 00185 Rome, Italy.ORCID 0000-0002-7983-2955
Cristina LimatolaIstituto di Ricovero e Cura a Carattere Scientifico, Neuromed, 86077 Pozzilli, Italy, cristina.limatola@uniroma1.it.ORCID 0000-0001-7504-8197
Istituto Neurologico Mediterraneo · ITItalian Institute of Technology · ITCzech Academy of Sciences, Institute of Physiology · CZIstituto di Nanotecnologia · ITIstituto Pasteur · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oleandrin is a glycoside that inhibits the ubiquitous enzyme Na

Indexed as

AnimalsBrain NeoplasmsCardenolidesCardiac GlycosidesCell Line, TumorCell SurvivalGliomaHumansMaleMiceMice, Inbred C57BLMice, SCIDMice, TransgenicTumor BurdenXenograft Model Antitumor AssaysCardenolidesCardiac GlycosidesoleandrinapoptosisBDNFgliomainvasionin vivooleandrin

Identifiers

PMID28292827
PMCPMC6596714
OpenAlexW2597037370

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.