Evidence map›Paper›PMID 28292759›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2017

Ovarian function's role during cancer cachexia progression in the female mouse.

Kimbell L Hetzler, Justin P Hardee, Holly A LaVoie, E Angela Murphy, James A Carson

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Hallmarks of Cancer Cachexia: Sexual Dimorphism in Related Pathways.International journal of molecular sciences · 2025
    Review
  8. Cancer Cachexia.Advances in experimental medicine and biology · 2025
    Review
  9. Cancer Cachexia.Advances in experimental medicine and biology · 2025
    Review
  10. Exploring heterogeneity: a dive into preclinical models of cancer cachexia.American journal of physiology. Cell physiology · 2024
    Review
  11. Article
  12. Article
  13. Sex Differences in Inflammation and Muscle Wasting in Aging and Disease.International journal of molecular sciences · 2023
    Review
  14. Article
  15. Article
  16. Muscular contraction's therapeutic potential for cancer-induced wasting.American journal of physiology. Cell physiology · 2022
    Review
  17. Article
  18. Skeletal muscle wasting: the estrogen side of sexual dimorphism.American journal of physiology. Cell physiology · 2022
    Review
  19. Article
  20. Nutrition challenges of cancer cachexia.JPEN. Journal of parenteral and enteral nutrition · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kimbell L HetzlerIntegrative Muscle Biology Laboratory, Department of Exercise Science, University of South Carolina, Columbia, South Carolina.
Justin P HardeeIntegrative Muscle Biology Laboratory, Department of Exercise Science, University of South Carolina, Columbia, South Carolina.
Holly A LaVoieDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina; and.
E Angela MurphyDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina; and.
James A CarsonIntegrative Muscle Biology Laboratory, Department of Exercise Science, University of South Carolina, Columbia, South Carolina; carsonj@mailbox.sc.edu.
University of South Carolina · US

Funding

TISSUE BIOREPOSITORY COREP30GM103336 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI PENA, MARIA MARJORETTE · 2013 to 2017
$5.4M
Biomedical-Behavioral Interface: Prevention and Developmental Sciences TrainingT32GM081740 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI PRINZ, RONALD J · 2008 to 2022
$4.5M
Cachexia in ApcMin/+ mice: The role of IL-6R01CA121249 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI CARSON, JAMES A · 2008 to 2018
$2.7M
Regulation of Macrophages in Obesity-Enhanced Colon Cancer:Benefits of QuercetinK01AT007824 · NCCIH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MURPHY, ELIZABETH ANGELA · 2013 to 2017
$632k
NCCIH NIH HHS K01 AT007824NCI NIH HHS R01 CA121249NIGMS NIH HHS P30 GM103336NIGMS NIH HHS T32 GM081740
6 · The paper itself

Abstract

Cachexia is a debilitating condition that occurs with chronic disease, including cancer; our research has shown that some regulation of cancer cachexia progression is affected by sex differences. The

Indexed as

Estrous CycleAdenomatous Polyposis ColiAnimalsCachexiaDisease ProgressionFemaleMiceMice, Inbred C57BLMice, TransgenicMuscle, SkeletalOvaryApcMin/+cancerIL-6, ovariectomyinflammation

Identifiers

PMID28292759
PMCPMC5451525
OpenAlexW2600561617

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.