Evidence map›Paper›PMID 28292711›Full record

ArticleRedox biology2017

CO-releasing molecules CORM2 attenuates angiotensin II-induced human aortic smooth muscle cell migration through inhibition of ROS/IL-6 generation and matrix metalloproteinases-9 expression.

Ming-Horng Tsai, Chiang-Wen Lee, Lee-Fen Hsu, Shu-Yu Li, Yao-Chang Chiang, Ming-Hsueh Lee, Chun-Han Chen, Hwey-Fang Liang, Jia-Mei How, Pey-Jium Chang and 2 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Redox biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
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  6. Nicardipine Inhibits Breast Cancer MigrationFrontiers in pharmacology · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Ming-Horng TsaiDepartment of Pediatrics, Division of Neonatology and Pediatric Hematology/Oncology, Chang Gung Memorial Hospital, Yunlin, Taiwan; Graduate Institute of Clinical Medical Science, College of Medicine, Chang Gung University, Taiwan.
Chiang-Wen LeeDepartment of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chia-Yi, Taiwan; Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Chia-Yi, Taiwan; Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan. Electronic address: cwlee@mail.cgust.edu.tw.
Lee-Fen HsuDepartment of Respiratory Care, Chang Gung University of Science and Technology, Chiayi Campus, Chiayi, Taiwan.
Shu-Yu LiDepartment of Pharmacy, College of Pharmacy & Health Care, Tajen University, Taiwan.
Yao-Chang ChiangCenter for Drug Abuse and Addiction, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Ming-Hsueh LeeDivision of Neurosurgery, Department of Surgery, Chang Gung Memorial Hospital, Chia-Yi 61363, Taiwan.
Chun-Han ChenDivision of General Surgery, Department of Surgery, Chang Gung Memorial Hospital at Chiayi, Chiayi, Taiwan.
Hwey-Fang LiangDepartment of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chia-Yi, Taiwan.
Jia-Mei HowSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Pey-Jium ChangGraduate Institute of Clinical Medical Science, College of Medicine, Chang Gung University, Taiwan.
Ching-Mei WuDepartment of Sports Medicine, College of Health Care, China Medical University, Taichung, Taiwan.
I-Ta LeeSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung, Taiwan. Electronic address: ita0128@mail.cmu.edu.tw.
China Medical University · TWChang Gung University of Science and Technology · TWChang Gung University · TWChiayi Chang Gung Memorial Hospital · TWTajen University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ang II has been involved in the pathogenesis of cardiovascular diseases, and matrix metalloproteinase-9 (MMP-9) induced migration of human aortic smooth muscle cells (HASMCs) is the most common and basic pathological feature. Carbon monoxide (CO), a byproduct of heme breakdown by heme oxygenase, exerts anti-inflammatory effects in various tissues and organ systems. In the present study, we aimed to investigate the effects and underlying mechanisms of carbon monoxide releasing molecule-2 (CORM-2) on Ang II-induced MMP-9 expression and cell migration of HASMCs. Ang II significantly up-regulated MMP-9 expression and cell migration of HASMCs, which was inhibited by transfection with siRNA of p47

Indexed as

Angiotensin IIAortaCell MovementGene Expression RegulationHumansInterleukin-6Matrix Metalloproteinase 9Muscle, Smooth, VascularMyocytes, Smooth MuscleNADPH OxidasesOrganometallic CompoundsOxidative StressReactive Oxygen SpeciesSignal TransductionAngiotensin IIInterleukin-6Matrix Metalloproteinase 9NADPH OxidasesOrganometallic CompoundsReactive Oxygen Speciestricarbonyldichlororuthenium (II) dimerAngiotensin IICarbon monoxideHuman aortic smooth muscle cellInflammationMatrix metallopeptidase-9

Identifiers

PMID28292711
PMCPMC5349464
OpenAlexW2594583185

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.