ReviewCurrent opinion in biotechnology2017
Bioresponsive transcutaneous patches.
Review in Current opinion in biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Non-transdermal microneedles for advanced drug delivery.Advanced drug delivery reviews · 2020Pooled it
- Targeting the Ras-Ral Signaling Axis in Type 2 Diabetes Mellitus: A Dual-Modulation Approach to Correcting Insulin Resistance and β-Cell Dysfunction.Pharmaceuticals (Basel, Switzerland) · 2026Review
- From conceptual design to translational progress: Emerging advances in intelligent microneedles for biomedical applications.Acta pharmaceutica Sinica. B · 2026Review
- Strategies for transportation of peptides across the skin for treatment of multiple diseases.Therapeutic delivery · 2025Review
- Construction and application of microneedle-mediated photothermal therapy and immunotherapy combined anti-tumor drug delivery system.Drug delivery · 2023Article
- Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Metformin Release.Global challenges (Hoboken, NJ) · 2023Article
- Digital health-high tech or high touch?Wiener medizinische Wochenschrift (1946) · 2023Article
- Promising Strategies for Transdermal Delivery of Arthritis Drugs: Microneedle Systems.Pharmaceutics · 2022Review
- Microneedle-mediated therapy for cardiovascular diseases.Drug delivery and translational research · 2022Article
- Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs.Nature biomedical engineering · 2020Article
- Recent progress in drug delivery.Acta pharmaceutica Sinica. B · 2019Review
- Advances in transdermal insulin delivery.Advanced drug delivery reviews · 2019Review
- Glucose-Responsive Microneedle Patches for Diabetes Treatment.Journal of diabetes science and technology · 2019Review
- Manganese dioxide nanosheets: from preparation to biomedical applications.International journal of nanomedicine · 2019Review
- Advances in bioresponsive closed-loop drug delivery systems.International journal of pharmaceutics · 2018Review
- Bioresponsive Microneedles with a Sheath Structure for HSmall (Weinheim an der Bergstrasse, Germany) · 2018Article
- Article
- Polymeric microneedles for transdermal protein delivery.Advanced drug delivery reviews · 2018Review
- Improving long-term subcutaneous drug delivery by regulating material-bioenvironment interaction.Advanced drug delivery reviews · 2018Review
- Exendin-4-encapsulated dissolving microneedle arrays for efficient treatment of type 2 diabetes.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Transdermal drug delivery systems that utilize transcutaneous patches of arrayed microneedles have attracted increasing interest in medical practice as an alternative method to hypodermic injection. Over the past ten years, research has focused on leveraging physiological signals associated with diseases or skin-specific tissues to create bioresponsive patches that release drug directly in response to an internally-generated stimulus. This review surveys the recent advances in the development and use of bioresponsive transcutaneous patches for on-demand smart and precise drug delivery, exploiting different physiological signals including pH, serum glucose levels, and enzyme activity. The clinical potential of these devices, including challenges and opportunities, is also discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.