Evidence map›Paper›PMID 28292531›Full record

ReviewNeuroscience and biobehavioral reviews2017

Stress, overeating, and obesity: Insights from human studies and preclinical models.

Maria Razzoli, Carolyn Pearson, Scott Crow, Alessandro Bartolomucci

Abstract readReview
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 1 pooled it
28.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 1 synthesis or guideline pooled it, 232 citations in OpenAlex.

  1. Pooled it
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  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Food insecurity promotes adiposity in mice.Obesity (Silver Spring, Md.) · 2025
    Article
  14. Review
  15. Review
  16. Review
  17. Obesity and metabolic disease in migrants: a role for the gut microbiome?Frontiers in clinical diabetes and healthcare · 2025
    Review
  18. Review
  19. Article
  20. Adverse childhood experiences and adult disease: Examining mediating pathways in the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2024
    Article

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Maria RazzoliDepartment of Integrative Biology and Physiology, University of Minnesota, 2231 6th Street SE, Minneapolis, MN 55455, USA.
Carolyn PearsonDepartment of Psychiatry, University of Minnesota, 2450 Riverside Avenue, Minneapolis, MN 55454, USA.
Scott CrowDepartment of Psychiatry, University of Minnesota, 2450 Riverside Avenue, Minneapolis, MN 55454, USA; The Emily Program, 2265 Como Avenue, St. Paul, MN 55108, USA.
Alessandro BartolomucciDepartment of Integrative Biology and Physiology, University of Minnesota, 2231 6th Street SE, Minneapolis, MN 55455, USA. Electronic address: abartolo@umn.edu.
University of Minnesota · US

Funding

Obesity and Energy Metabolism CoreP30DK050456 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI CROW, SCOTT J · 1995 to 2015
$17.0M
ENERGETICS DISPARITIES & LIFESPAN: A UNIFIED HYPOTHESISR01AG043972 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ALLISON, DAVID B · 2012 to 2016
$8.3M
Regional Postdoctoral Training Grant in Eating Disorders ResearchT32MH082761 · NIMH · UNIVERSITY OF MINNESOTA · PI CAROL B. PETERSON · 2009 to 2026
$6.2M
Molecular dissection of TLQP-21 peptide functions in obesityR01DK102496 · NIDDK · UNIVERSITY OF MINNESOTA · PI BARTOLOMUCCI, ALESSANDRO · 2014 to 2018
$1.7M
NIA NIH HHS R01 AG043972NIDDK NIH HHS P30 DK050456NIDDK NIH HHS R01 DK102496NIMH NIH HHS T32 MH082761
6 · The paper itself

Abstract

Eating disorders and obesity have become predominant in human society. Their association to modern lifestyle, encompassing calorie-rich diets, psychological stress, and comorbidity with major diseases are well documented. Unfortunately the biological basis remains elusive and the pharmacological treatment inadequate, in part due to the limited availability of valid animal models. Human research on binge eating disorder (BED) proves a strong link between stress exposure and bingeing: state-levels of stress and negative affect are linked to binge eating in individuals with BED both in laboratory settings and the natural environment. Similarly, classical animal models of BED reveal an association between acute exposure to stressors and binging but they are often associated with unchanged or decreased body weight, thus reflecting a negative energy balance, which is uncommon in humans where most commonly BED is associated with excessive or unstable body weight gain. Recent mouse models of subordination stress induce spontaneous binging and hyperphagia, altogether more closely mimicking the behavioral and metabolic features of human BED. Therefore the translational relevance of subordination stress models could facilitate the identification of the neurobiological basis of BED and obesity-associated disease and inform on the development of innovative therapies.

Indexed as

HyperphagiaObesityStress, PsychologicalAnimalsEnergy MetabolismHumansMiceAnimal modelChronic subordination stressEcological momentary assessmentNegative affectSocial stressStress

Identifiers

PMID28292531
PMCPMC5403578
OpenAlexW2594369816

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.