Evidence map›Paper›PMID 28292091›Full record

ArticleThe Pan African medical journal2016

[Performance of GeneXpert MTB / RIF

Awa Ba Diallo, Abdoulkader Issifi Kollo, Makhtar Camara, Seynabou Lo, Gedeon Walbang Ossoga, Moustapha Mbow, Farba Karam, Mame Yacine Fall Niang, Aliou Thiam, Awa Ndiaye Diawara and 2 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Pan African medical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 6 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 6 syntheses or guidelines pooled it, 20 citations in OpenAlex.

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  6. XpertThe Cochrane database of systematic reviews · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Awa Ba DialloLaboratoire de Bactériologie, Virologie du CHNU Aristide Le Dantec, Sénégal; Département des Sciences Biologiques, Université Cheikh Anta Diop, Dakar, Sénégal.
Abdoulkader Issifi KolloLaboratoire de Bactériologie, Virologie du CHNU Aristide Le Dantec, Sénégal.
Makhtar CamaraLaboratoire de Bactériologie, Virologie du CHNU Aristide Le Dantec, Sénégal; Département des Sciences Biologiques, Université Cheikh Anta Diop, Dakar, Sénégal.
Seynabou LoUFR Sciences de la Santé, Université Gaston Berger, Saint Louis.
Gedeon Walbang OssogaLaboratoire de Bactériologie, Virologie du CHNU Aristide Le Dantec, Sénégal.
Moustapha MbowLaboratoire de Bactériologie, Virologie du CHNU Aristide Le Dantec, Sénégal.
Farba KaramLaboratoire de Bactériologie, Virologie du CHNU Aristide Le Dantec, Sénégal.
Mame Yacine Fall NiangLaboratoire de Bactériologie, Virologie du CHNU Aristide Le Dantec, Sénégal.
Aliou ThiamLaboratoire de Bactériologie, Virologie du CHNU Aristide Le Dantec, Sénégal.
Awa Ndiaye DiawaraLaboratoire de Bactériologie, Virologie du CHNU Aristide Le Dantec, Sénégal.
Souleymane MboupLaboratoire de Bactériologie, Virologie du CHNU Aristide Le Dantec, Sénégal.
Aissatou Gaye DialloLaboratoire de Bactériologie, Virologie du CHNU Aristide Le Dantec, Sénégal.
Hôpital Aristide Le Dantec · SNCheikh Anta Diop University · SNUniversité Gaston Berger · SN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe challenge facing developing countries is the availability of methods for rapid and accurate diagnosis of tuberculosis. Some molecular techniques offer this advantage, so we used GeneXpert MTB / RIF test in the diagnosis of extra-pulmonary tuberculosis to evaluate its performance compared with conventional methods.

methodsBetween 2010 and 2015, 544 extrapulmonary clinical specimens were collected and analyzed by microscopy, culture and GeneXpert. The evaluation of antitubercular susceptibility testing was performed using the MGIT 960 system. Genotype MTBDRplus was used to confirm the cases of rifampicin resistance detected by the GX system.

resultsThe study population included 544 patients, 55.15% men and 44.85% women. Patients age ranged from 1-92 years with the majority in the 18-45 age group. The sensitivity and the overall specificity of microscopy was 43.86% and 98.36%, 94.74% and 97.95% for GeneXpert

conclusionThis study shows that the GeneXpert test exhibits high sensitivity for routine diagnosis of extra-pulmonary tuberculosis and should be used instead of microscopy. The cases of rifampicin resistance detected by GeneXpert should be confirmed by other molecular testing methods before initiating treatment.

Indexed as

AdolescentAdultAgedAged, 80 and overAntitubercular AgentsChildChild, PreschoolDrug Resistance, BacterialFemaleGenotypeHumansInfantMaleMicrobial Sensitivity TestsMicroscopyMiddle AgedAntitubercular AgentsRifampinDakarextra-pulmonary tuberculosisGeneXpert MTB/RIF

Identifiers

PMID28292091
PMCPMC5325514
OpenAlexW2548433938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.