ArticlePloS one2017
Microstructural white matter alterations in preclinical Alzheimer's disease detected using free water elimination diffusion tensor imaging.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed.
- Free water: A marker of age-related modifications of the cingulum white matter and its association with cognitive decline.PloS one · 2020Trial
- Plasma inflammatory markers and brain white matter microstructure in late middle-aged and older adults.Neurobiology of aging · 2026Article
- Biophysical Diffusion MRI Models Better Identify White Matter Tracts in Edema.Tomography (Ann Arbor, Mich.) · 2026Article
- Dysregulated oligodendrocyte and myelin dynamics as an early pathological feature of neuropil degeneration in Alzheimer's disease: an ultrastructural study.Acta neuropathologica communications · 2026Article
- Free Water Elevation in Alzheimer's Disease: Influence of Amyloid-Beta Deposition Beyond Brain Cell Loss.Journal of Korean medical science · 2026Article
- Neuroimaging Correlates of the NIH Toolbox Cognition and Trail Making Tests: Normative Benchmarks in Healthy Aging.Clinical and translational neuroscience · 2026Article
- Association between perivascular diffusion and white matter microstructural integrity, free water, Aβ burden, and cognition: diffusion tensor vs. kurtosis tensor.Frontiers in aging neuroscience · 2026Article
- Imaging markers of neuroinflammation in aging and Alzheimer's disease and related dementia: A comprehensive review.Neuroscience and biobehavioral reviews · 2025Review
- Mapping Alzheimer's disease pathology using free water through integrated analysis of plasma biomarkers, microstructural DTI metrics, and macrostructural MRI measures.Scientific reports · 2025Article
- In Vivo Cortical Microstructure: Relationships With Tauopathy and Cognitive Impairment in the Elderly.Journal of neurochemistry · 2025Article
- White Matter Abnormalities and Cognition in Aging and Alzheimer Disease.JAMA neurology · 2025Article
- Regional free-water diffusion is more strongly related to neuroinflammation than neurodegeneration.Journal of neurology · 2025Article
- Layer-Dependent Effect of Aβ-Pathology on Cortical Microstructure With Ex Vivo Human Brain Diffusion MRI at 7 Tesla.Human brain mapping · 2025Article
- The effect of Alzheimer's disease genetic factors on limbic white matter microstructure.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Thalamic microstructural alterations in cerebral small vessel disease with mild cognitive impairment: insights from diffusion kurtosis imaging.Neuroradiology · 2025Article
- Del Río Hortega's insights into oligodendrocytes: recent advances in subtype characterization and functional roles in axonal support and disease.Frontiers in neuroanatomy · 2025Review
- White Matter Injury in Central Nervous System Disorders.Neuropsychiatric disease and treatment · 2025Review
- Free-water: A promising structural biomarker for cognitive decline in aging and mild cognitive impairment.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Matrix metalloproteinase 9 (MMP-9) activity, hippocampal extracellular free water, and cognitive deficits are associated with each other in early phase psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Brain white matter microstructural alterations in patients with systemic lupus erythematosus: an automated fiber quantification study.Brain imaging and behavior · 2024Article
23 more citing papers are in PubMed but not listed here.
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11 authors.
Funding
Abstract
Brain changes associated with Alzheimer's disease (AD) begin decades before disease diagnosis. While β-amyloid plaques and neurofibrillary tangles are defining features of AD, neuronal loss and synaptic pathology are closely related to the cognitive dysfunction. Brain imaging methods that are tuned to assess degeneration of myelinated nerve fibers in the brain (collectively called white matter) include diffusion tensor imaging (DTI) and related techniques, and are expected to shed light on disease-related loss of structural connectivity. Participants (N = 70, ages 47-76 years) from the Wisconsin Registry for Alzheimer's Prevention study underwent DTI and hybrid diffusion imaging to determine a free-water elimination (FWE-DTI) model. The study assessed the extent to which preclinical AD pathology affects brain white matter. Preclinical AD pathology was determined using cerebrospinal fluid (CSF) biomarkers. The sample was enriched for AD risk (APOE ε4 and parental history of AD). AD pathology assessed by CSF analyses was significantly associated with altered microstructure on both DTI and FWE-DTI. Affected regions included frontal, parietal, and especially temporal white matter. The f-value derived from the FWE-DTI model appeared to be the most sensitive to the relationship between the CSF AD biomarkers and microstructural alterations in white matter. These findings suggest that white matter degeneration is an early pathological feature of AD that may have utility both for early disease detection and as outcome measures for clinical trials. More complex models of microstructural diffusion properties including FWE-DTI may provide increased sensitivity to early brain changes associated with AD over standard DTI.
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