ArticlePLoS medicine2017
Mixed pathologies and neural reserve: Implications of complexity for Alzheimer disease drug discovery.
Article in PLoS medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed.
- Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies.Annals of neurology · 2019Trial
- Brain pathology in relation to somatic diseases: Exploring the body-brain crosstalk.Journal of internal medicine · 2026Review
- Neuropathologic Profiles and Associated Cognitive Trajectories in Community-Living Older Adults.JAMA network open · 2026Article
- Identifying motor resilience proteins associated with motor decline in older adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Moderate-to-Vigorous Physical Activity at any Dose Reduces All-Cause Dementia Risk Regardless of Frailty Status.Journal of the American Medical Directors Association · 2025Article
- Exploring temporal and sex-linked dysregulation in Alzheimer disease phosphoproteome.iScience · 2024Article
- Assessment of neurovascular uncoupling: APOE status is a key driver of early metabolic and vascular dysfunction.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Characterizing molecular and synaptic signatures in mouse models of late-onset Alzheimer's disease independent of amyloid and tau pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Assessment of Neurovascular Uncoupling:bioRxiv : the preprint server for biology · 2024Article
- Brain-age estimation with a low-cost EEG-headset: effectiveness and implications for large-scale screening and brain optimization.Frontiers in neuroergonomics · 2024Article
- Characterizing Molecular and Synaptic Signatures in mouse models of Late-Onset Alzheimer's Disease Independent of Amyloid and Tau Pathology.bioRxiv : the preprint server for biology · 2023Article
- A Federated Learning Model Based on Hardware Acceleration for the Early Detection of Alzheimer's Disease.Sensors (Basel, Switzerland) · 2023Article
- Pathological combinations in neurodegenerative disease are heterogeneous and disease-associated.Brain : a journal of neurology · 2023Article
- Correlates of Person-Specific Rates of Change in Sensor-Derived Physical Activity Metrics of Daily Living in the Rush Memory and Aging Project.Sensors (Basel, Switzerland) · 2023Article
- NHANES 2011-2014 Reveals Decreased Cognitive Performance in U.S. Older Adults with Metabolic Syndrome Combinations.International journal of environmental research and public health · 2023Article
- Proteome-Wide Discovery of Cortical Proteins That May Provide Motor Resilience to Offset the Negative Effects of Pathologies in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Brain Aging Among Racially and Ethnically Diverse Middle-Aged and Older Adults.JAMA neurology · 2023Article
- Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer's disease.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Testing the amyloid cascade hypothesis: Prevention trials in autosomal dominant Alzheimer disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Association of AK4 Protein From Stem Cell-Derived Neurons With Cognitive Reserve: An Autopsy Study.Neurology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
In a Perspective, David Bennett makes a case for neural reserve to be considered as a therapeutic endpoint in clinical trials for dementia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.