ArticleProceedings of the National Academy of Sciences of the United States of America1988
Structural alteration in the MYB protooncogene and deletion within the gene encoding alpha-type protein kinase C in human melanoma cell lines.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 59 citations in OpenAlex.
- Building an ensemble learning model for gastric cancer cell line classification via rapid raman spectroscopy.Computational and structural biotechnology journal · 2023Article
- Dynamic adhesions and MARCKS in melanoma cells.Journal of cell science · 2009Article
- Src, PKCalpha, and PKCdelta are required for alphavbeta3 integrin-mediated metastatic melanoma invasion.Cell communication and signaling : CCS · 2009Article
- A single point mutation in the V3 region affects protein kinase Calpha targeting and accumulation at cell-cell contacts.Molecular and cellular biology · 2001Article
- Selective loss of substrate recognition induced by the tumour-associated D294G point mutation in protein kinase Calpha.The Biochemical journal · 1998Article
- Involvement of the ALL-1 gene in a solid tumor.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Biologic and therapeutic significance of MYB expression in human melanoma.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Growth factor independence and growth regulatory pathways in human melanoma development.Cancer metastasis reviews · 1993Review
- Protein kinase C beta expression in melanoma cells and melanocytes: differential expression correlates with biological responses to 12-O-tetradecanoylphorbol 13-acetate.Journal of cancer research and clinical oncology · 1993Article
- Transformation of murine melanocytes by basic fibroblast growth factor cDNA and oncogenes and selective suppression of the transformed phenotype in a reconstituted cutaneous environment.The Journal of cell biology · 1989Article
- A protein kinase C cDNA without the regulatory domain is active after transfection in vivo in the absence of phorbol ester.Molecular and cellular biology · 1989Article
- Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Isolation of human cDNA clones of myb-related genes, A-myb and B-myb.Nucleic acids research · 1988Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
A correlative study was done to determine possible relationships between nonrandom aberrations in chromosomes 1, 6, and 7 occurring in human cutaneous malignant melanoma and the structure of oncogenes as well as specific genes encoding growth factors and growth factor receptors. Thirty cell lines derived from primary or metastatic melanomas of 28 patients were analyzed by Southern blotting with nick-translated probes for 28 different genes, some of which map near frequent chromosomal breakpoints observed in melanoma. An alteration in the MYB protooncogene was observed in a cell line derived from a primary melanoma in the vertical growth phase, which correlated with a 6q22 chromosomal abnormality. Another primary melanoma cell line had a cytogenetically undetected tumor-specific deletion within the gene for alpha-type protein kinase C. Polymorphic alleles for the genes encoding the epidermal growth factor receptor and alpha-type protein kinase C were also observed.
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