ArticleProceedings of the National Academy of Sciences of the United States of America1988
Olfaction by melanophores: what does it mean?
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 36 citations in OpenAlex.
- Review
- Functional Characterization of the Odorant Receptor 51E2 in Human Melanocytes.The Journal of biological chemistry · 2016Article
- Selective imaging of presynaptic activity in the mouse olfactory bulb shows concentration and structure dependence of odor responses in identified glomeruli.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Characterization of a serotonin receptor endogenous to frog melanophores.Naunyn-Schmiedeberg's archives of pharmacology · 1994Article
- Intracellular cyclic AMP not calcium, determines the direction of vesicle movement in melanophores: direct measurement by fluorescence ratio imaging.The Journal of cell biology · 1992Article
- Chemosensory responses in isolated olfactory receptor neurons from Necturus maculosus.The Journal of general physiology · 1992Article
- Membrane fluidity changes of liposomes in response to various odorants. Complexity of membrane composition and variety of adsorption sites for odorants.Biophysical journal · 1990Article
- Cell cultures of neuroblasts from rat olfactory epithelium that show odorant responses.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Odorant response of isolated olfactory receptor cells is blocked by amiloride.The Journal of membrane biology · 1988Article
- Basic fibroblast growth factor from human keratinocytes is a natural mitogen for melanocytes.The Journal of cell biology · 1988Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypotheses on general olfaction can be divided into two broad groups: those that predict the existence of olfactory-specific olfactory receptor proteins and those that do not. Recently, much attention has been paid to the discovery of an odorant-stimulated adenylate cyclase in purified olfactory cilia. This finding has, for the most part, been accepted as evidence that the former hypotheses are correct. Here we report that frog melanophores, which are nonolfactory in nature, disperse their melanosomes in response to the same types and concentrations of odorants used in the investigations of olfactory cilia and that pigment dispersion is accompanied by rises in intracellular cAMP levels. The effects show that the existence of a cAMP-based second messenger system in olfactory cilia is not in itself proof of the existence of olfactory-specific olfactory receptor proteins. Also they explain the basis of Ottoson's pioneering work of 30 years ago on the electrical responses of frog olfactory epithelium to stimulation with alcohols. The results suggest that there could be two mechanisms that are important for the detection of odorants: one based on specific receptors, the other nonspecific, but both working through activation of cAMP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.