ArticleTranslational psychiatry2017
Abnormal white matter structural connectivity in adults with obsessive-compulsive disorder.
Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- White matter abnormalities in paediatric obsessive-compulsive disorder: a systematic review of diffusion tensor imaging studies.Brain imaging and behavior · 2023Pooled it
- Microstructural white matter abnormalities in pediatric and adult obsessive-compulsive disorder: A systematic review and meta-analysis.Brain and behavior · 2021Pooled it
- Altered thalamo–cortical and occipital–parietal– temporal–frontal white matter connections in patients with anorexia and bulimia nervosa: a systematic review of diffusion tensor imaging studiesJournal of psychiatry & neuroscience : JPN · 2019Pooled it
- Home-Based Individualized Alpha Transcranial Alternating Current Stimulation Improves Symptoms of Obsessive-Compulsive Disorder: Preliminary Evidence from a Randomized, Sham-Controlled Clinical Trial.Depression and anxiety · 2023Trial
- Neuroimaging and Machine Learning in OCD: Advances in Diagnostic and Therapeutic Insights.Brain sciences · 2025Review
- Abnormal spontaneous regional white-matter brain activity in patients with obsessive-compulsive disorder.Frontiers in psychology · 2025Article
- Translating Molecular Approaches to Oligodendrocyte-Mediated Neurological Circuit Modulation.Brain sciences · 2024Review
- Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure.Molecular psychiatry · 2024Article
- Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder.National science review · 2023Article
- Characteristics of white matter structural connectivity in healthy adults with childhood maltreatment.European journal of psychotraumatology · 2023Article
- Structural Connectivity Reorganization Based on DTI after Cingulotomy in Obsessive-Compulsive Disorder.Brain sciences · 2022Article
- Maturational Indices of the Cognitive Control Network Are Associated with Inhibitory Control in Early Childhood.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Quantitative mapping of the brain's structural connectivity using diffusion MRI tractography: A review.NeuroImage · 2022Review
- Association between gray/white matter contrast and white matter microstructural alterations in medication-naïve obsessive-compulsive disorder.NeuroImage. Clinical · 2022Article
- Reduced Axon Calibre in the Associative Striatum of theBrain sciences · 2021Article
- Cellular and Extracellular White Matter Abnormalities in Obsessive-Compulsive Disorder: A Diffusion Magnetic Resonance Imaging Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Altered white matter structural networks in drug-naïve patients with obsessive-compulsive disorder.Brain imaging and behavior · 2021Article
- White matter microstructure and its relation to clinical features of obsessive-compulsive disorder: findings from the ENIGMA OCD Working Group.Translational psychiatry · 2021Article
- White matter microstructural and Compulsive Sexual Behaviors Disorder - Diffusion Tensor Imaging study.Journal of behavioral addictions · 2021Review
- An association of Myelin Oligodendrocyte Glycoprotein (MOG) gene variants with white matter volume in pediatric obsessive-compulsive disorder.Psychiatry research. Neuroimaging · 2021Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obsessive-compulsive disorder (OCD) is a complex and severe psychiatric disorder whose pathogenesis is not fully understood. Recent studies have shown white matter (WM) alterations in adults with OCD, but the results have been inconsistent. The present study investigated WM structure in OCD patients with the hypothesis that large-scale brain networks may be disrupted in OCD. A total of 24 patients with OCD and 23 healthy controls (HCs) were scanned with diffusion tensor imaging. A tract-based spatial statistics (TBSS) approach was used to detect differences across the whole brain in patients with OCD vs HCs; post hoc fiber tractography was applied to characterize developmental differences between the two groups. Relative to HCs, patients with OCD had lower fractional anisotropy (FA) values in the corpus callosum (CC), left anterior corona radiata (ACR), left superior corona radiata (SCR) and left superior longitudinal fasciculus (SLF), and higher radial diffusivity in the genu and body of CC. Among the TBSS de-projected region of interest results, compared with HCs, patients with OCD showed lower of the mean FA values of fiber bundles passing though the SLF, and shorter lengths of ACR, SCR and CC. In conclusion, this study provides novel evidence of widespread microstructural alterations in OCD and suggests that OCD may involve abnormalities affecting a broader network of regions than commonly believed.
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