ArticleScientific reports2017
Influence of ad Libitum Feeding of Piglets With Bacillus Subtilis Fermented Liquid Feed on Gut Flora, Luminal Contents and Health.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Dietary Fiber Regulation of Gut Microbiota and Bile Acid Metabolism in Animals: Implications for Animal Nutrition.Veterinary sciences · 2026Review
- Cross-sectional study characterizing the porcine faecal microbiome in commercial farms.Porcine health management · 2026Article
- Profiling the bacteriome of a diet fed in meal or pelleted form, delivered as dry, wet/dry, or liquid feed and its impact on the fecal and intestinal bacteriome of grow-finisher pigs.Journal of animal science · 2026Article
- A comparative study of gut microbiota and metabolites in Tibetan sheep during cold and warm seasons.Frontiers in veterinary science · 2026Article
- Impact of fermented liquid feed supplementation on grower-fattening pigs production: Insights into growth performance, carcass traits, meat quality, and metabolite profiles.Food chemistry. Molecular sciences · 2025Article
- Bacteriome and mycobiome profiling of liquid feed for finisher pigs on commercial pig farms.Scientific reports · 2025Article
- Bacillus subtilis: current and future modification strategies as a protein secreting factory.World journal of microbiology & biotechnology · 2024Review
- The Use of Fruit and Vegetable by-Products as Enhancers of Health Status of Piglets after Weaning: The Role of Bioactive Compounds from Apple and Carrot Industrial Wastes.Veterinary sciences · 2023Review
- Effect of Supplementing aAnimals : an open access journal from MDPI · 2023Article
- Alleviative Effect of Probiotic Ferment onBiology · 2023Article
- Gut microbiota-derived ursodeoxycholic acid alleviates low birth weight-induced colonic inflammation by enhancing M2 macrophage polarization.Microbiome · 2023Article
- Alginate Alleviates Dextran Sulfate Sodium-Induced Colitis by Promoting Bifidobacterium animalis and Intestinal Hyodeoxycholic Acid Synthesis in Mice.Microbiology spectrum · 2022Article
- Coated tannin supplementation improves growth performance, nutrients digestibility, and intestinal function in weaned piglets.Journal of animal science · 2022Article
- Positive Interventional Effect of Engineered Butyrate-Producing Bacteria on Metabolic Disorders and Intestinal Flora Disruption in Obese Mice.Microbiology spectrum · 2022Article
- Fecal Microbial Changes in Response to Finishing Pigs Directly Fed With Fermented Feed.Frontiers in veterinary science · 2022Article
- Microbial Quality of Liquid Feed for Pigs and Its Impact on the Porcine Gut Microbiome.Animals : an open access journal from MDPI · 2021Review
- Mycotoxin Removal byToxins · 2021Article
- Effects of Microbial Fermented Feed on Serum Biochemical Profile, Carcass Traits, Meat Amino Acid and Fatty Acid Profile, and Gut Microbiome Composition of Finishing Pigs.Frontiers in veterinary science · 2021Article
- Two antimicrobial genes from Aegilops tauschii Cosson identified by the Bacillus subtilis expression system.Scientific reports · 2020Article
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Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some scholars caution that long-term ad libitum feeding with probiotic fermented food poses potential health risks to baby animals. We conducted a feeding experiment to investigate the influence of ad libitum feeding of pre-and post-weaned piglets with a Bacillus subtilis fermented diet on the gut microbiome, gut metabolomic profiles, bile acid metabolism, proinflammatory cytokines and faecal consistency. Compared with piglets fed a Bacillus subtilis-supplemented pellet diet, piglets fed the Bacillus subtilis fermented liquid diet had lower intestinal bacterial diversity (P > 0.05), higher intestinal fungal diversity (P > 0.05), more Firmicutes (P > 0.05), fewer Bacteroidetes, Actinobacteria and Proteobacteria (P > 0.05), higher concentrations of 3-hydroxypropionic acid (P < 0.05), orotic acid (P < 0.05), interleukin-6 (P < 0.01), lactic acid (P < 0.01), deoxycholic acid (P > 0.05) and lithocholic acid (P < 0.01) and a higher incidence of diarrhoea (P > 0.05). The data show that ad libitum feeding of piglets with a Bacillus subtilis fermented liquid diet during the suckling and early post-weaning periods promotes the growth of lactic acid bacteria, bile salt hydrolase-active bacteria and 7a-dehydroxylase-active bacteria in the intestinal lumen; disturbs the normal production of lactic acid, orotic acid and unconjugated bile acids; and increases circulating interleukin-6 levels and diarrhoea incidence.
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Registered trials
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