Evidence map›Paper›PMID 28291248›Full record

ArticleScientific data2017

A curated collection of tissue microarray images and clinical outcome data of prostate cancer patients.

Qing Zhong, Tiannan Guo, Markus Rechsteiner, Jan H Rüschoff, Niels Rupp, Christian Fankhauser, Karim Saba, Ashkan Mortezavi, Cédric Poyet, Thomas Hermanns and 4 more

Open access · goldAbstract readDataset
In one paragraph

Article in Scientific data, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Aberrations of DNA Repair Pathways in Prostate Cancer-The State of the Art.International journal of molecular sciences · 2023
    Article
  7. Review
  8. Inferring clonal composition from multiple tumor biopsies.NPJ systems biology and applications · 2020
    Article
  9. Article
  10. Article
  11. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Qing ZhongDepartment of Pathology and Molecular Pathology, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID 0000-0002-5340-301X
Tiannan GuoDepartment of Biology, Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland.ORCID 0000-0003-3869-7651
Markus RechsteinerDepartment of Pathology and Molecular Pathology, University Hospital Zurich, 8091 Zurich, Switzerland.
Jan H RüschoffDepartment of Pathology and Molecular Pathology, University Hospital Zurich, 8091 Zurich, Switzerland.
Niels RuppDepartment of Pathology and Molecular Pathology, University Hospital Zurich, 8091 Zurich, Switzerland.
Christian FankhauserDepartment of Urology, University Hospital Zurich, 8091 Zurich, Switzerland.
Karim SabaDepartment of Urology, University Hospital Zurich, 8091 Zurich, Switzerland.
Ashkan MortezaviDepartment of Urology, University Hospital Zurich, 8091 Zurich, Switzerland.
Cédric PoyetDepartment of Urology, University Hospital Zurich, 8091 Zurich, Switzerland.
Thomas HermannsDepartment of Urology, University Hospital Zurich, 8091 Zurich, Switzerland.
Yi ZhuDepartment of Biology, Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland.
Holger MochDepartment of Pathology and Molecular Pathology, University Hospital Zurich, 8091 Zurich, Switzerland.
Ruedi AebersoldDepartment of Biology, Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland.
Peter J WildDepartment of Pathology and Molecular Pathology, University Hospital Zurich, 8091 Zurich, Switzerland.
University Hospital of Zurich · CHETH Zurich · CHUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microscopy image data of human cancers provide detailed phenotypes of spatially and morphologically intact tissues at single-cell resolution, thus complementing large-scale molecular analyses, e.g., next generation sequencing or proteomic profiling. Here we describe a high-resolution tissue microarray (TMA) image dataset from a cohort of 71 prostate tissue samples, which was hybridized with bright-field dual colour chromogenic and silver in situ hybridization probes for the tumour suppressor gene PTEN. These tissue samples were digitized and supplemented with expert annotations, clinical information, statistical models of PTEN genetic status, and computer source codes. For validation, we constructed an additional TMA dataset for 424 prostate tissues, hybridized with FISH probes for PTEN, and performed survival analysis on a subset of 339 radical prostatectomy specimens with overall, disease-specific and recurrence-free survival (maximum 167 months). For application, we further produced 6,036 image patches derived from two whole slides. Our curated collection of prostate cancer data sets provides reuse potential for both biomedical and computational studies.

Indexed as

ProteomicsGene Expression ProfilingHigh-Throughput Nucleotide SequencingHumansMaleProstatectomyProstatic NeoplasmsPTEN PhosphohydrolasePTEN PhosphohydrolasePTEN protein, human

Identifiers

PMID28291248
PMCPMC5349242
OpenAlexW2747085440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.