ArticleScientific reports2017
Continuous-flow DNP polarizer for MRI applications at 1.5 T.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Zero-Field Overhauser Dynamic Nuclear Polarization.ACS omega · 2025Article
- Spin Hyperpolarization in Modern Magnetic Resonance.Chemical reviews · 2023Review
- Functionalized Controlled Porous Glasses for Producing Radical-Free Hyperpolarized Liquids by Overhauser DNP.Molecules (Basel, Switzerland) · 2022Article
- Optical Dynamic Nuclear Polarization ofMolecules (Basel, Switzerland) · 2022Article
- Overhauser dynamic nuclear polarization (ODNP)-enhanced two-dimensional proton NMR spectroscopy at low magnetic fields.Magnetic resonance (Gottingen, Germany) · 2021Article
- Increased flow rate of hyperpolarized aqueous solution for dynamic nuclear polarization-enhanced magnetic resonance imaging achieved by an open Fabry-Pérot type microwave resonator.Magnetic resonance (Gottingen, Germany) · 2020Article
- SQUID-based ultralow-field MRI of a hyperpolarized material using signal amplification by reversible exchange.Scientific reports · 2019Article
- Injection And Infusion Technology Disruption For Use In MRI.Medical devices (Auckland, N.Z.) · 2019Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we describe a new hyperpolarization approach for magnetic resonance imaging applications at 1.5 T. Proton signal enhancements of more than 20 were achieved with a newly designed multimode microwave resonator situated inside the bore of the imager and used for Overhauser dynamic nuclear polarization of the water proton signal. Different from other approaches in our setup the hyperpolarization is achieved continuously by liquid water flowing through the polarizer under continuous microwave excitation. With an available flow rate of up to 1.5 ml/min, which should be high enough for DNP MR angiography applications in small animals like mice and rats. The hyperpolarized liquid cooled to physiological temperature can be routed by a mechanical switch to a quartz capillary for injection into the blood vessels of the target object. This new approach allows hyperpolarization of protons without the need of an additional magnet and avoids the losses arising from the transfer of the hyperpolarized solution between magnets. The signal-to-noise improvement of this method is demonstrated on two- and three-dimensional phantoms of blood vessels.
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