ArticleScientific reports2017
Gut dysbiosis and neuroimmune responses to brain infection with Theiler's murine encephalomyelitis virus.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- The Commensal Microbiota and Viral Infection: A Comprehensive Review.Frontiers in immunology · 2019Pooled it
- Co-infection with a viral pathogen (Theiler's murine encephalomyelitis virus) tended to improve host tolerance but significantly enhanced resistance to Heligmosomoides bakeri.Veterinary research communications · 2026Article
- Gut Microbiota in a Viral Model of Multiple Sclerosis: Modulation and Pitfalls by Oral Antibiotic Treatment.Cells · 2025Article
- Gut microbiota in multiple sclerosis and animal models.The FEBS journal · 2025Review
- Application of Theiler's murine encephalomyelitis virus in treatment of multiple sclerosis.Frontiers in microbiology · 2024Review
- Review
- Microbiota, IgA and Multiple Sclerosis.Microorganisms · 2022Review
- Importance of crosstalk between the microbiota and the neuroimmune system for tissue homeostasis.Clinical & translational immunology · 2022Review
- Microbiome Methods in Experimental Autoimmune Encephalomyelitis.Current protocols · 2021Article
- The Interaction Between Viruses and Intestinal Microbiota: A Review.Current microbiology · 2021Review
- Aging and neuroinflammation: Changes in immune cell responses, axon integrity, and motor function in a viral model of progressive multiple sclerosis.Aging cell · 2021Article
- Identification of the Ghrelin and Cannabinoid CBInternational journal of molecular sciences · 2021Article
- Article
- Viral and Prion Infections Associated with Central Nervous System Syndromes in Brazil.Viruses · 2021Review
- Neuroimmune crosstalk and evolving pharmacotherapies in neurodegenerative diseases.Immunology · 2021Review
- Intestinal Microbiota-A Promising Target for Antiviral Therapy?Frontiers in immunology · 2021Review
- How oral probiotics affect the severity of an experimental model of progressive multiple sclerosis? Bringing commensal bacteria into the neurodegenerative process.Gut microbes · 2020Article
- Gut dysbiosis induced by cardiac pressure overload enhances adverse cardiac remodeling in a T cell-dependent manner.Gut microbes · 2020Article
- Gut microbiome variation is associated to Multiple Sclerosis phenotypic subtypes.Annals of clinical and translational neurology · 2020Article
- Bioinformatics Analysis of Gut Microbiota and CNS Transcriptome in Virus-Induced Acute Myelitis and Chronic Inflammatory Demyelination; Potential Association of Distinct Bacteria With CNS IgA Upregulation.Frontiers in immunology · 2020Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have begun to point out the contribution of microbiota to multiple sclerosis (MS) pathogenesis. Theiler's murine encephalomyelitis virus induced demyelinating disease (TMEV-IDD) is a model of progressive MS. Here, we first analyze the effect of intracerebral infection with TMEV on commensal microbiota and secondly, whether the early microbiota depletion influences the immune responses to TMEV on the acute phase (14 dpi) and its impact on the chronic phase (85 dpi). The intracranial inoculation of TMEV was associated with a moderate dysbiosis. The oral administration of antibiotics (ABX) of broad spectrum modified neuroimmune responses to TMEV dampening brain CD4
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.