ArticleScientific reports2017
Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 62 citations in OpenAlex.
- The Inflammatory Response in the Murine Ovalbumin-Induced Skin Inflammation Model Is Robust Despite Major Gut Microbiota Differences.Clinical and translational science · 2026Article
- A Refined Method for Fecal Microbiota Transplantation Using Nutella.Clinical and translational science · 2026Article
- Gastrointestinal Intraluminal pH of Non-Fasted Mice (Mus musculus) of Various Strains and Vendors Including Germ-Free and Streptomycin-Treated Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Fecal microbiota transplantation for the treatment of chronic inflammatory skin diseases.Heliyon · 2024Review
- Preclinical Development of SHR-1819, a Potent Humanized IL-4Rα Antibody for Treating Type 2 Inflammatory Diseases.Journal of inflammation research · 2024Article
- Association Between Atopic Dermatitis and Aging: Clinical Observations and Underlying Mechanisms.Journal of inflammation research · 2024Review
- Cesarean section induced dysbiosis promotes type 2 immunity but not oxazolone-induced dermatitis in mice.Gut microbes · 2023Article
- Atopic Dermatitis: Beyond the Skin and Into the Gut.Journal of clinical medicine · 2023Article
- Quantifying Inflammatory Response and Drug-Aided Resolution in an Atopic Dermatitis Model with Deep Learning.The Journal of investigative dermatology · 2023Article
- A Review on Maternal and Infant Microbiota and Their Implications for the Prevention and Treatment of Allergic Diseases.Nutrients · 2023Review
- Toll-like receptors: their roles in pathomechanisms of atopic dermatitis.Frontiers in immunology · 2023Review
- Tryptophan, an important link in regulating the complex network of skin immunology response in atopic dermatitis.Frontiers in immunology · 2023Review
- An Altered Skin and Gut Microbiota Are Involved in the Modulation of Itch in Atopic Dermatitis.Cells · 2022Review
- Controlling the uncontrolled variation in the diet induced obese mouse by microbiomic characterization.Scientific reports · 2022Article
- Manipulating Microbiota to Treat Atopic Dermatitis: Functions and Therapies.Pathogens (Basel, Switzerland) · 2022Review
- Article
- A proof of concept infant-microbiota associated rat model for studying the role of gut microbiota and alleviation potential ofFrontiers in nutrition · 2022Article
- Implications of Gut Microbiota in Complex Human Diseases.International journal of molecular sciences · 2021Review
- The microbiome and rodent models of immune mediated diseases.Mammalian genome : official journal of the International Mammalian Genome Society · 2021Review
- An Oligosaccharide Rich Diet IncreasesFrontiers in microbiology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atopic Dermatitis (AD) has been associated with gut microbiota (GM) dysbiosis in humans, indicating a causative role of GM in AD etiology. Furthermore, the GM strongly correlates to essential disease parameters in the well-known oxazolone-induced mouse model of AD. Here, we demonstrate that it is possible to transfer both a high-responding and a low-responding AD phenotype with GM from conventional mice to germ-free mice. The mice inoculated with the high-responding GM had significantly higher clinical score, increased ear thickness, and increased levels of IL-1β, TNFα, IL-4, IL-5, and IL-6 compared to the mice inoculated with the low-responding GM. The inter-individual variation was in general not affected by this increase in effect size. Germ-free mice induced with AD revealed a high disease response as well as high inter-individual variation indicating protective properties of certain microbial taxa in this model. This study underlines that the GM has a strong impact on AD in mouse models, and that the power of studies may be increased by the application of mice inoculated with a specific GM from high responders to increase the effect size.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.