ArticleScientific reports2017
An outbreak of severe infections among Australian infants caused by a novel recombinant strain of human parechovirus type 3.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Review
- Parechovirus infection in human brain organoids: host innate inflammatory response and not neuro-infectivity correlates to neurologic disease.Nature communications · 2024Article
- Parechovirus A Circulation and Testing Capacities in Europe, 2015-2021.Emerging infectious diseases · 2024Review
- Novel Human Parechovirus 3 Diversity, Recombination, and Clinical Impact Across 7 Years: An Australian Story.The Journal of infectious diseases · 2023Article
- Neurodevelopmental outcomes of newborns and infants with parechovirus and enterovirus central nervous infection: a 5-year longitudinal study.European journal of pediatrics · 2022Article
- Genetic Variations in Human Parechovirus Type 3 in Infants with Central Nervous System Infection.Virologica Sinica · 2021Article
- Metagenomic characterisation of additional and novel avian viruses from Australian wild ducks.Scientific reports · 2020Article
- Potential neuroinvasive and neurotrophic properties of SARS-CoV-2 in pediatric patients: comparison of SARS-CoV-2 with non-segmented RNA viruses.Journal of neurovirology · 2020Article
- Metagenomic characterisation of avian parvoviruses and picornaviruses from Australian wild ducks.Scientific reports · 2020Article
- An Emerging Human Parechovirus Type 5 Causing Sepsis-Like Illness in Infants in Australia.Viruses · 2019Article
- Epidemiology of Human Parechovirus Type 3 Upsurge in 2 Hospitals, Freiburg, Germany, 2018.Emerging infectious diseases · 2019Article
- Evolutionary analysis of human parechovirus type 3 and clinical outcomes of infection during the 2017-18 Australian epidemic.Scientific reports · 2019Article
- Seroepidemiology of Parechovirus A3 Neutralizing Antibodies, Australia, the Netherlands, and United States.Emerging infectious diseases · 2019Article
- Metagenomics detection and characterisation of viruses in faecal samples from Australian wild birds.Scientific reports · 2018Article
- 2017 international meeting of the Global Virus Network.Antiviral research · 2018Article
- Strain-dependent neutralization reveals antigenic variation of human parechovirus 3.Scientific reports · 2017Article
- Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3.Scientific reports · 2017Article
- The Complete Genome Sequence of a Human Parechovirus from a Child with Diarrhea in China Revealed Intertypic Recombination.Genome announcements · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human parechovirus types 1-16 (HPeV1-16) are positive strand RNA viruses in the family Picornaviridae. We investigated a 2015 outbreak of HPeV3 causing illness in infants in Victoria, Australia. Virus genome was extracted from clinical material and isolates and sequenced using a combination of next generation and Sanger sequencing. The HPeV3 outbreak genome was 98.7% similar to the HPeV3 Yamagata 2011 lineage for the region encoding the structural proteins up to nucleotide position 3115, but downstream of that the genome varied from known HPeV sequences with a similarity of 85% or less. Analysis indicated that recombination had occurred, may have involved multiple types of HPeV and that the recombination event/s occurred between March 2012 and November 2013. However the origin of the genome downstream of the recombination site is unknown. Overall, the capsid of this virus is highly conserved, but recombination provided a different non-structural protein coding region that may convey an evolutionary advantage. The indication that the capsid encoding region is highly conserved at the amino acid level may be helpful in directing energy towards the development of a preventive vaccine for expecting mothers or antibody treatment of young infants with severe disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.