ArticleScientific reports2017
Transcriptome analysis of a wild bird reveals physiological responses to the urban environment.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 128 citations in OpenAlex.
- The impact of urbanization on health depends on the health metric, life stage and level of urbanization: a global meta-analysis on avian species.Proceedings. Biological sciences · 2024Pooled it
- Macroimmunology: The drivers and consequences of spatial patterns in wildlife immune defence.The Journal of animal ecology · 2020Pooled it
- Landscape transcriptomics reveals ecological constraints on fish under anthropogenic coastal change.Nature communications · 2026Article
- Evolution under the city's shadow: reproductive divergence of urban and rural great tits revealed by a common garden experiment.Evolution letters · 2026Article
- When Does Stress Build Strength? Linking Stress Physiology to Resilience in the Age of Rapid Environmental Change.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- The Transcriptomic Response Along an Urbanization Gradient Is Also Temperature-Dependent in a Freshwater Insect.Molecular ecology · 2026Article
- Transcriptomic differences in immune- and stress-related pathways associated with artificial rearing in the endangered hog deer (Axis porcinus).BMC genomics · 2026Article
- The rise of historical epigenomics and temporal analysis of gene regulation.Genome biology · 2025Review
- Landscape transcriptomics as a tool for addressing global change effects across diverse species.Molecular ecology resources · 2025Review
- Life at new extremes: Integrating stress physiology and the bio-exposome in the Anthropocene.Annals of the New York Academy of Sciences · 2025Review
- Assessment of Oxidative Stress and Associated Biomarkers in Wild Avian Species.Animals : an open access journal from MDPI · 2025Review
- The One Health approach in urban ecosystem rehabilitation: An evidence-based framework for designing sustainable cities.iScience · 2024Review
- Short-term dietary changes are reflected in the cerebral content of adult ring-billed gulls.Royal Society open science · 2024Article
- Dietary fatty acids modulate oxidative stress response to air pollution but not to infection.Frontiers in physiology · 2024Article
- Interactive effects of rising temperatures and urbanisation on birds across different climate zones: A mechanistic perspective.Global change biology · 2023Review
- Feather corticosterone reveals that urban great tits experience lower corticosterone exposure than forest individuals during dominance-rank establishment.Conservation physiology · 2023Article
- Sex differences in immune gene expression in the brain of a small shorebird.Immunogenetics · 2022Article
- Population density mediates induced immune response, but not physiological condition in a well-adapted urban bird.Scientific reports · 2022Article
- Stress-induced changes in body surface temperature are repeatable, but do not differ between urban and rural birds.Oecologia · 2022Article
- Historical museum samples enable the examination of divergent and parallel evolution during invasion.Molecular ecology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identifying the molecular basis of environmentally induced phenotypic variation presents exciting opportunities for furthering our understanding of how ecological processes and the environment can shape the phenotype. Urban and rural environments present free-living organisms with different challenges and opportunities, which have marked consequences for the phenotype, yet little is known about responses at the molecular level. We characterised transcriptomes from an urban and a rural population of great tits Parus major, demonstrating striking differences in gene expression profiles in both blood and liver tissues. Differentially expressed genes had functions related to immune and inflammatory responses, detoxification, protection against oxidative stress, lipid metabolism, and regulation of gene expression. Many genes linked to stress responses were expressed at higher levels in the urban birds, in accordance with our prediction that urban animals are exposed to greater environmental stress. This is one of the first studies to reveal transcriptional differences between urban- and rural-dwelling animals and suggests an important role for epigenetics in mediating environmentally induced physiological variation. The study provides valuable resources for developing further in-depth studies of the mechanisms driving phenotypic variation in the urban context at larger spatial and temporal scales.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.