Evidence map›Paper›PMID 28290453›Full record

ArticleNature communications2017

Suppressive IL-17A

Stephanie Downs-Canner, Sara Berkey, Greg M Delgoffe, Robert P Edwards, Tyler Curiel, Kunle Odunsi, David L Bartlett, Nataša Obermajer

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 1 synthesis or guideline pooled it, 179 citations in OpenAlex.

  1. Pooled it
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  20. Animal models for transplant immunology: bridging bench to bedside.Clinical transplantation and research · 2024
    Review

57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Stephanie Downs-CannerDepartment of Surgical Oncology, University of Pittsburgh, 5150 Centre Avenue, Pittsburgh, Pennsylvania 15213, USA.
Sara BerkeyDepartment of Surgical Oncology, University of Pittsburgh, 5150 Centre Avenue, Pittsburgh, Pennsylvania 15213, USA.
Greg M DelgoffeUniversity of Pittsburgh Cancer Institute, 5150 Centre Avenue, Pittsburgh, Pennsylvania 15213, USA.
Robert P EdwardsUniversity of Pittsburgh Cancer Institute, 5150 Centre Avenue, Pittsburgh, Pennsylvania 15213, USA.
Tyler CurielUT Health Science Center at San Antonio, 8403 Floyd Curl Drive, San Antonio, Texas 78229, USA.
Kunle OdunsiDepartments of Gynecologic Oncology and Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA.
David L BartlettDepartment of Surgical Oncology, University of Pittsburgh, 5150 Centre Avenue, Pittsburgh, Pennsylvania 15213, USA.
Nataša ObermajerDepartment of Surgical Oncology, University of Pittsburgh, 5150 Centre Avenue, Pittsburgh, Pennsylvania 15213, USA.
University of Pittsburgh · USUPMC Hillman Cancer Center · USRoswell Park Comprehensive Cancer Center · USThe University of Texas Health Science Center at San Antonio · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MARK G FRATTINI · 1985 to 2026
$116.6M
RPCI-UPCI Ovarian Cancer SPOREP50CA159981 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MOYSICH, KIRSTEN B. · 2013 to 2025
$19.6M
Postdoctoral Research Training in Biotherapy of CancerT32CA113263 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Udai S Kammula · 2006 to 2026
$3.6M
NCI NIH HHS P30 CA016056NCI NIH HHS P30 CA016086NCI NIH HHS P50 CA159981NCI NIH HHS T32 CA113263
6 · The paper itself

Abstract

Th17 and regulatory T (T

Indexed as

Adenocarcinoma, Clear CellAdultAgedAged, 80 and overAnimalsAntigens, CDCell Line, TumorCell TransdifferentiationCytokinesFemaleFlow CytometryForkhead Transcription FactorsGene Expression ProfilingHomeostasisHumansImmune Tolerancealpha E integrinsAntigens, CDCytokinesfolate receptor 4, mouseForkhead Transcription FactorsFoxp3 protein, mouseIcos protein, mouseIl17a protein, mouseIl1rl1 protein, mouseInducible T-Cell Co-Stimulator ProteinIntegrin alpha Chainsintegrin beta8Integrin beta ChainsInterleukin-17Interleukin-1 Receptor-Like 1 ProteinLrrc32 protein, mouseMembrane ProteinsNuclear Receptor Subfamily 1, Group F, Member 3Pglyrp1 protein, mouseReceptors, Cell SurfaceReceptors, ImmunologicRorc protein, mouseT cell Ig and ITIM domain protein, mouse

Identifiers

PMID28290453
PMCPMC5355894
OpenAlexW2613214396

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.