ArticleMolecular neurobiology2018
Extracellular Matrix Modulation Is Driven by Experience-Dependent Plasticity During Stroke Recovery.
Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Environmental enrichment modulates chronic poststroke inflammation and links white matter TREM2-positive microglia in recovery in mice.Neuroprotection (Chichester, England) · 2026Article
- Nrg1 regulates cortical wiring and motor recovery upon traumatic injury.Frontiers in cellular neuroscience · 2026Article
- Modified human mesenchymal stromal/stem cells restore cortical excitability after focal ischemic stroke in rats.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Morphological and Molecular Characteristics of Perineuronal Nets in the Human Prefrontal Cortex-A Possible Link to Microcircuitry Specialization.Molecular neurobiology · 2025Article
- Advanced rehabilitation in ischaemic stroke research.Stroke and vascular neurology · 2024Review
- Environmental Enrichment in Stroke Research: an Update.Translational stroke research · 2024Review
- Article
- Environmental enrichment enhanced neurogenesis and behavioral recovery after stroke in aged rats.Aging · 2023Article
- A Novel In Vivo Model for Multiplexed Analysis of Callosal Connections upon Cortical Damage.International journal of molecular sciences · 2022Article
- Recovery of Post-Stroke Spatial Memory and Thalamocortical Connectivity Following Novel Glycomimetic and rhBDNF Treatment.International journal of molecular sciences · 2022Article
- The Important Double-Edged Role of Astrocytes in Neurovascular Unit After Ischemic Stroke.Frontiers in aging neuroscience · 2022Review
- A glial perspective on the extracellular matrix and perineuronal net remodeling in the central nervous system.Frontiers in cellular neuroscience · 2022Review
- Microglia as hackers of the matrix: sculpting synapses and the extracellular space.Cellular & molecular immunology · 2021Review
- Mimicking Extracellular Matrix via Engineered Nanostructured Biomaterials for Neural Repair.Current neuropharmacology · 2021Review
- Roadmap for Stroke: Challenging the Role of the Neuronal Extracellular Matrix.International journal of molecular sciences · 2020Review
- Transcriptional Response and Morphological Features of the Neurovascular Unit and Associated Extracellular Matrix After Experimental Stroke in Mice.Molecular neurobiology · 2019Article
- Should We Care About Early Post-Stroke Rehabilitation? Not Yet, but Soon.Current neurology and neuroscience reports · 2019Review
- Loss of GABAThe Journal of physiology · 2018Article
- Changes in resting-state functional connectivity after stroke in a mouse brain lacking extracellular matrix components.Neurobiology of disease · 2018Article
- The Perineuronal 'Safety' Net? Perineuronal Net Abnormalities in Neurological Disorders.Frontiers in molecular neuroscience · 2018Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Following stroke, complete cellular death in the ischemic brain area may ensue, with remaining brain areas undergoing tissue remodelling to various degrees. Experience-dependent brain plasticity exerted through an enriched environment (EE) promotes remodelling after central nervous system injury, such as stroke. Post-stroke tissue reorganization is modulated by growth inhibitory molecules differentially expressed within the ischemic hemisphere, like chondroitin sulfate proteoglycans found in perineuronal nets (PNNs). PNNs in the neocortex predominantly enwrap parvalbumin-containing GABAergic (PV/GABA) neurons, important in sensori-information processing. Here, we investigate how extracellular matrix (ECM) proteases and their inhibitors may participate in the regulation of PNN integrity during stroke recovery. Rats were subjected to photothrombotic stroke in the motor cortex, and functional deficits were assessed at 7 days of recovery. Sham and stroked rats were housed in either standard or EE conditions for 5 days, and infarct volumes were calculated. PNNs were visualized by immunohistochemistry and counted in the somatosensory cortex of both hemispheres. mRNA expression levels of ECM proteases and protease inhibitors were assessed by RT-qPCR and their activity analyzed by gel zymography. PNNs and protease activity were also studied in brains from stroke patients where similar results were observed. EE starting 2 days after stroke and continuing for 5 days stimulated behavioral recovery of limb-placement ability without affecting infarct size. EE promoted a decrease of PNNs around PV/GABA neurons and a concomitant modulation of the proteolytic activity and mRNA expression of ECM proteases and protease inhibitors in the somatosensory cortex. This study provides molecular targets for novel therapies that could support rehabilitation of stroke patients.
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