Evidence map›Paper›PMID 28290057›Full record

Trial reportEuropean journal of applied physiology2017

Intestinal fatty acid-binding protein and gut permeability responses to exercise.

Daniel S March, Tania Marchbank, Raymond J Playford, Arwel W Jones, Rhys Thatcher, Glen Davison

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of applied physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 9 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 9 syntheses or guidelines pooled it, 96 citations in OpenAlex.

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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 1 country.

Daniel S MarchDepartment of Infection, Immunity and Inflammation, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, UK.
Tania MarchbankCentre for Immunobiology, Blizard Institute, Barts and The London School of Medicine, Queen Mary University of London, London, UK.
Raymond J PlayfordPeninsula Medical School, Plymouth University, The John Bull Building, Tamar Science Park, Research Way, Plymouth, UK.
Arwel W JonesLincoln Institute for Health, University of Lincoln, Lincoln, UK.
Rhys ThatcherInstitute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth, UK.
Glen DavisonEndurance Research Group, School of Sport and Exercise Sciences, University of Kent, Medway Campus, Chatham Maritime, ME4 4AG, UK. g.davison@kent.ac.uk.ORCID http://orcid.org/0000-0003-4340-0074
Aberystwyth University · GBMedway School of Pharmacy · GBQueen Mary University of London · GBUniversity of Leicester · GBUniversity of Lincoln · GBUniversity of Plymouth · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIntestinal cell damage due to physiological stressors (e.g. heat, oxidative, hypoperfusion/ischaemic) may contribute to increased intestinal permeability. The aim of this study was to assess changes in plasma intestinal fatty acid-binding protein (I-FABP) in response to exercise (with bovine colostrum supplementation, Col, positive control) and compare this to intestinal barrier integrity/permeability (5 h urinary lactulose/rhamnose ratio, L/R).

methodsIn a double-blind, placebo-controlled, crossover design, 18 males completed two experimental arms (14 days of 20 g/day supplementation with Col or placebo, Plac). For each arm participants performed two baseline (resting) intestinal permeability assessments (L/R) pre-supplementation and one post-exercise following supplementation. Blood samples were collected pre- and post-exercise to determine I-FABP concentration.

resultsTwo-way repeated measures ANOVA revealed an arm × time interaction for L/R and I-FABP (P < 0.001). Post hoc analyses showed urinary L/R increased post-exercise in Plac (273% of pre, P < 0.001) and Col (148% of pre, P < 0.001) with post-exercise values significantly lower with Col (P < 0.001). Plasma I-FABP increased post-exercise in Plac (191% of pre-exercise, P = 0.002) but not in the Col arm (107%, P = 0.862) with post-exercise values significantly lower with Col (P = 0.013). Correlations between the increase in I-FABP and L/R were evident for visit one (P = 0.044) but not visit two (P = 0.200) although overall plots/patterns do appear similar for each.

conclusionThese findings suggest that exercise-induced intestinal cellular damage/injury is partly implicated in changes in permeability but other factors must also contribute.

Indexed as

ExerciseIntestinal AbsorptionAdultAnimalsCattleColostrumFatty Acid-Binding ProteinsHumansIntestinal MucosaLactuloseMaleRhamnoseFatty Acid-Binding ProteinsLactuloseRhamnoseBovine colostrumCell damageCellular injuryCore temperatureIntestinal permeabilityStrenuous exerciseUrinary L/R

Identifiers

PMID28290057
PMCPMC5388720
OpenAlexW2597114149

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.