Evidence map›Paper›PMID 28290050›Full record

ArticleDrug delivery and translational research2017

Micellar nano-carriers for the delivery of STAT3 dimerization inhibitors to melanoma.

Amir H Soleimani, Shyam M Garg, Igor M Paiva, Mohammad R Vakili, Abdulraheem Alshareef, Yung-Hsing Huang, Ommoleila Molavi, Raymond Lai, Afsaneh Lavasanifar

Abstract read
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In one paragraph

Article in Drug delivery and translational research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Unraveling the complexity of STAT3 in cancer: molecular understanding and drug discovery.Journal of experimental & clinical cancer research : CR · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Amir H SoleimaniFaculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Shyam M GargFaculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Igor M PaivaFaculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Mohammad R VakiliFaculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Abdulraheem AlshareefFaculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Yung-Hsing HuangFaculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Ommoleila MolaviFaculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Raymond LaiFaculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Afsaneh LavasanifarFaculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada. afsaneh@ualberta.ca.ORCID http://orcid.org/0000-0001-5108-7124
University of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this research was to develop polymeric micellar formulations of inhibitors of signal transducer and activator of transcription 3 (STAT3) dimerization, i.e., S3I-1757 and S3I-201, and evaluate the activity of successful formulations in B16-F10 melanoma, a STAT3 hyperactive cancer model, in vitro and in vivo. STAT3 inhibitory agents were encapsulated in methoxy poly(ethylene oxide)-b-poly(ε-caprolactone) (PEO

Indexed as

MicellesAminosalicylic AcidsAnimalsAntineoplastic AgentsBenzenesulfonatesCell Line, TumorCell SurvivalDendritic CellsDimerizationDrug CarriersDrug LiberationFemaleLactonesMelanoma, ExperimentalMice, Inbred C57BLNanoparticlesAminosalicylic AcidsAntineoplastic AgentsBenzenesulfonatesDrug CarriersLactonesMicellesNSC 74859PolyestersPolyethylene Glycolspoly(ethylene oxide)-b-poly(alpha-benzyl carboxylate epsilon-caprolactone)poly(ethylene oxide)-b-poly(caprolactone)Stat3 protein, mouseSTAT3 Transcription FactorVascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseB16-F10Polymeric micellesS3I-1757STAT3 inhibition

Identifiers

PMID28290050
OpenAlexW2596712222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.