ArticleEuropean radiology2017
The effect of hippocampal function, volume and connectivity on posterior cingulate cortex functioning during episodic memory fMRI in mild cognitive impairment.
Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
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- Deficient Novelty Detection and Encoding in Early Alzheimer's Disease: An ERP Study.Brain topography · 2022Article
- Combining PET with MRI to improve predictions of progression from mild cognitive impairment to Alzheimer's disease: an exploratory radiomic analysis study.Annals of translational medicine · 2022Article
- Neural mechanisms associated with semantic and basic self-oriented memory processes interact moderating self-esteem.iScience · 2022Article
- Neural basis of topographical disorientation in the primate posterior cingulate gyrus based on a labeled graph.AIMS neuroscience · 2022Article
- Cholinergic Denervation Patterns Across Cognitive Domains in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Decreased Alpha Peak Frequency Is Linked to Episodic Memory Impairment in Pathological Aging.Frontiers in aging neuroscience · 2021Article
- Effects of gene mutation and disease progression on representative neural circuits in familial Alzheimer's disease.Alzheimer's research & therapy · 2020Article
- Stimulation of the Posterior Cingulate Cortex Impairs Episodic Memory Encoding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesDiminished function of the posterior cingulate cortex (PCC) is a typical finding in early Alzheimer's disease (AD). It is hypothesized that in early stage AD, PCC functioning relates to or reflects hippocampal dysfunction or atrophy. The aim of this study was to examine the relationship between hippocampus function, volume and structural connectivity, and PCC activation during an episodic memory task-related fMRI study in mild cognitive impairment (MCI).
methodMCI patients (n = 27) underwent episodic memory task-related fMRI, 3D-T1w MRI, 2D T2-FLAIR MRI and diffusion tensor imaging. Stepwise linear regression analysis was performed to examine the relationship between PCC activation and hippocampal activation, hippocampal volume and diffusion measures within the cingulum along the hippocampus.
resultsWe found a significant relationship between PCC and hippocampus activation during successful episodic memory encoding and correct recognition in MCI patients. We found no relationship between the PCC and structural hippocampal predictors.
conclusionsOur results indicate a relationship between PCC and hippocampus activation during episodic memory engagement in MCI. This may suggest that during episodic memory, functional network deterioration is the most important predictor of PCC functioning in MCI. KEY POINTS: • PCC functioning during episodic memory relates to hippocampal functioning in MCI. • PCC functioning during episodic memory does not relate to hippocampal structure in MCI. • Functional network changes are an important predictor of PCC functioning in MCI.
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