Evidence map›Paper›PMID 28289900›Full record

ArticleVirchows Archiv : an international journal of pathology2017

Fhit down-regulation is an early event in pancreatic carcinogenesis.

Matteo Fassan, Borislav Rusev, Vincenzo Corbo, Pierluigi Gasparini, Claudio Luchini, Caterina Vicentini, Andrea Mafficini, Salvatore Paiella, Roberto Salvia, Ivana Cataldo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Matteo FassanARC-NET Research Centre, Department of Diagnostics and Public Health, University of Verona, Verona, Italy. matteo.fassan@unipd.it.ORCID http://orcid.org/0000-0001-6515-5482
Borislav RusevARC-NET Research Centre, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
Vincenzo CorboARC-NET Research Centre, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
Pierluigi GaspariniComprehensive Cancer Center, Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA.
Claudio LuchiniARC-NET Research Centre, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
Caterina VicentiniARC-NET Research Centre, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
Andrea MafficiniARC-NET Research Centre, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
Salvatore PaiellaDepartment of Surgery, Unit of General Surgery B, University and Hospital Trust of Verona, Verona, Italy.
Roberto SalviaDepartment of Surgery, Unit of General Surgery B, University and Hospital Trust of Verona, Verona, Italy.
Ivana CataldoARC-NET Research Centre, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
Aldo ScarpaARC-NET Research Centre, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
Kay HuebnerComprehensive Cancer Center, Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA.
University of Verona · ITThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · US

Funding

Wwox as a Critical Signal Mediator in Breast CancerR01CA120516 · NCI · OHIO STATE UNIVERSITY · PI HUEBNER, KAY · 2006 to 2013
$1.3M
NCI NIH HHS R01 CA120516
6 · The paper itself

Abstract

Aberrant Fhit expression characterizes a large proportion of primary pancreatic ductal adenocarcinomas (PDACs), but fragmentary information is available on Fhit expression during the phenotypic changes of pancreatic ductal epithelium during multistep transformation. We assessed Fhit expression by immunohistochemistry in two different multistep pancreatic carcinogenic processes: pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasia (IPMN). We considered 105 surgically treated PDACs/IPMNs and selected 30 samples of non-neoplastic pancreatic parenchyma, 50 PanIN lesions, 30 IPMNs, 15 IPMNs with associated invasive carcinoma, and 60 adenocarcinomas. Normal pancreatic ducts and surrounding acinar cells consistently showed moderate to strong Fhit immunoreactivity. Significant down-regulation of Fhit expression was observed in association with increasing severity of dysplastia/neoplastia in both carcinogenic processes. This was further confirmed by studying multiple lesions obtained from the same surgical specimen. Of 60 PDACs, only 14 showed Fhit expression comparable to normal pancreatic ductal epithelium, while the remainder (77%) showed clearly negative or reduced Fhit expression. This study demonstrates that Fhit down-regulation is an early event in both multistep carcinogenic processes leading to PDAC.

Indexed as

Acid Anhydride HydrolasesAdultAgedBis(5'-adenosyl)triphosphataseCarcinoma in SituCarcinoma, Pancreatic DuctalCell Transformation, NeoplasticDown-RegulationFemaleHumansImmunohistochemistryMaleMiddle AgedNeoplasm ProteinsPancreatic NeoplasmsRetrospective StudiesAcid Anhydride HydrolasesBis(5'-adenosyl)triphosphataseNeoplasm ProteinsBiomarkersCarcinogenesisFHITPancreatic cancer

Identifiers

PMID28289900
PMCPMC5568551
OpenAlexW2595449329

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.