Evidence map›Paper›PMID 28289896›Full record

ArticleJournal of cancer research and clinical oncology2017

Incidence and outcomes of acute kidney injury in patients with hepatocellular carcinoma after liver transplantation.

Xiaohong Chen, Xiaoqiang Ding, Bo Shen, Jie Teng, Jianzhou Zou, Ting Wang, Jian Zhou, Nan Chen, Boheng Zhang

Abstract read
In one paragraph

Article in Journal of cancer research and clinical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Observational
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Assessing risk factors of acute kidney injury after liver transplantation.Journal of cancer research and clinical oncology · 2017
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Xiaohong ChenBlood Purification Center, Zhongshan Hospital of Fudan University, Shanghai, 200032, People's Republic of China.
Xiaoqiang DingBlood Purification Center, Zhongshan Hospital of Fudan University, Shanghai, 200032, People's Republic of China. ding.xiaoqiang@zs-hospital.sh.cn.
Bo ShenBlood Purification Center, Zhongshan Hospital of Fudan University, Shanghai, 200032, People's Republic of China.
Jie TengBlood Purification Center, Zhongshan Hospital of Fudan University, Shanghai, 200032, People's Republic of China.
Jianzhou ZouBlood Purification Center, Zhongshan Hospital of Fudan University, Shanghai, 200032, People's Republic of China.
Ting WangDepartment of Liver Surgery, Zhongshan Hospital of Fudan University, Shanghai, 200032, People's Republic of China.
Jian ZhouDepartment of Liver Surgery, Zhongshan Hospital of Fudan University, Shanghai, 200032, People's Republic of China.
Nan ChenIntensive Care Unit, Shanghai Public Health Clinical Center, Zhongshan Hospital of Fudan University, Shanghai, 200032, People's Republic of China.
Boheng ZhangLiver Cancer Institute, Shanghai, 200032, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo describe the incidence and outcomes linked with acute kidney injury (AKI) after liver transplantation (LT) in hepatocellular carcinoma (HCC) patients.

methodsFrom January 2003 to February 2011, HCC patients undergoing LT were retrospectively enrolled. Patient with a glomerular filtration rate (GFR) <60 mL/min/1.73 m

resultsOf the 566 eligible patients, AKI was found in 109 (19.26%) patients (stage I, 66 cases; stage II, 15 cases; and stage III, 28 cases). Risk factors for AKI were the long anhepatic time (OR = 3.59, P = 0.009) and prolonged duration of systolic blood pressure (SBP) < 90 mmHg (OR = 1.07, P < 0.0001). Post-LT AKI was an independent risk factor associated with 30-day mortality (HR = 4.05, P = 0.047). Complete recovery occurred in 84 (77.06%) of all AKI episodes within 1 month after operation, while 25 patients (22.94%) suffered from prolonged AKI. Patients with prolonged AKI had a poorer 1-year survival than those with transient AKI (40 vs 86.90%; P < 0.0001). Patients with severe AKI more often developed prolonged AKI. 13 patients (52%) of the prolonged AKI progressed to chronic kidney disease (CKD) defined as eGFR <60 mL/min/1.73 m

conclusionsPost-LT AKI is not an uncommon complication. Intra-operative hemodynamic instability is crucial in the development of post-LT AKI and deserves more attention. Most post-LT AKI is transient and reversible, while the prolonged form may predict a decrease survival.

Indexed as

Acute Kidney InjuryAdultAgedCarcinoma, HepatocellularFemaleHumansIncidenceLiver NeoplasmsLiver TransplantationMaleMiddle AgedPostoperative ComplicationsRetrospective StudiesRisk FactorsTreatment OutcomeAcute kidney injuryChronic kidney diseaseHepatocellular carcinomaLiver transplantationMortalityRisk

Identifiers

PMID28289896
PMCPMC11819420

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.