ArticleWorld journal of surgery2017
The Impact of Anastomotic Leakage on Anal Function Following Intersphincteric Resection.
Article in World journal of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Association between anastomotic leak after rectal resection and bowel dysfunction, a systematic review, meta-analysis and meta-regression.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Pooled it
- A multicentre prospective study of anal function after laparoscopic ultra-low rectal cancer surgery using a mixed-effects model.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Trial
- Short-term outcomes of laparoscopic intersphincteric resection with intraoperative radiotherapy using low-energy X-rays for primary locally advanced low rectal cancer: a single center experience.World journal of surgical oncology · 2020Trial
- Textbook anastomotic success in patients with low rectal cancer treated by intersphincteric resection: reappraising surgical, oncological, and functional outcomes.Updates in surgery · 2024Article
- Does anastomotic leakage after intersphincteric resection for ultralow rectal cancer influence long-term outcomes? A retrospective observational study.Langenbeck's archives of surgery · 2023Observational
- Can the Single-stapling Technique Following Intersphincteric Resection with Transanal Total Mesorectal Excision Become the New Standard Anastomosis?Journal of the anus, rectum and colon · 2023Review
- The effect of anastomotic leak on postoperative pelvic function and quality of life in rectal cancer patients.Discover oncology · 2022Review
- Clinical effects of prophylactic transverse colostomy in patients undergoing completely laparoscopic transabdominal approach partial intersphincteric resection.The Journal of international medical research · 2022Article
- Trans-Anastomotic Drainage Tube Placement After Hand-Sewn Anastomosis in Patients Undergoing Intersphincteric Resection for Low Rectal Cancer: An Alternative Drainage Method.Frontiers in oncology · 2022Article
- Nomogram for Predicting the Probability of Permanent Stoma after Laparoscopic Intersphincteric Resection.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Article
- Sacral neuromodulation for the prevention of a permanent stoma in patients with severe defecation disorder following intersphincteric resection.Surgery today · 2021Article
- Multicenter investigation of bowel evacuation function after transanal total mesorectal excision for mid-low rectal cancer.International journal of colorectal disease · 2021Article
- Management guidelines for low anterior resection syndrome - the MANUEL project.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2021Article
- Risk Factors for Anorectal Dysfunction After Interspincteric Resection in Patients With Low Rectal Cancer.Frontiers in surgery · 2021Article
- Risk factors for parastomal hernia of loop stoma and relationships with other stoma complications in laparoscopic surgery era.BMC surgery · 2020Article
- Risk factors for the incidence and severity of peristomal skin disorders defined using two scoring systems.Surgery today · 2020Article
- Ultimate Functional Preservation With Intersphincteric Resection for Rectal Cancer.Frontiers in oncology · 2020Review
- Latest Advances in Intersphincteric Resection for Low Rectal Cancer.Gastroenterology research and practice · 2020Review
- Validation of the Japanese Version of the Low Anterior Resection Syndrome Score.World journal of surgery · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundData regarding anastomotic leakage (AL) following intersphincteric resection (ISR) are lacking. We aimed to evaluate the effect of AL on anal function in a retrospective review of patients who developed AL following ISR.
methodsWe evaluated 341 consecutive patients who underwent ISR between 2000 and 2012. Patients were classified into three groups: anastomotic dehiscence (AD), major AL (Clavien-Dindo grade III+), or control (<grade III or no AL). Functional assessment was performed at 3, 6, 12, and 24 months after defecation through the preserved anus, and the Wexner score was calculated.
resultsAmong patients who underwent ISR for low rectal cancer (anal verge, 3.7 ± 1.3 cm), 59 (17%) developed AL. Of these, 13 patients were classified as AD and 36 as major AL. The rate of the 3-year stomal reversal was significantly lower in the major AL (78.6%) and AD groups (61.5%) than in the control group (88.7%; p < 0.01). Furthermore, the anastomotic stricture rate was higher in the AL and AD groups than in the controls (16.7 and 38.5 vs. 1.8%, respectively; p < 0.01). Wexner scores in the major AL group were poor during the early period, but were similar to the control group at the 2-year follow-up. In contrast, Wexner scores in the AD group remained high, even after 2 years.
conclusionsPatients with major AL following ISR had poor anal function that recovered over 2 years, as long as AD was not present. These findings suggest that patients with major AL require a long-term follow-up for anal function.
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