ArticleWorld journal of plastic surgery2017
Effect of Basic Fibroblast Growth Factor on Achilles Tendon Healing in Rabbit.
Article in World journal of plastic surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Platelet-rich plasma injection for the treatment of chronic Achilles tendinopathy: A meta-analysis.Medicine · 2019Pooled it
- Grafts in tendon repair.Materials today. Bio · 2026Review
- The use of molecular cues to regenerate musculoskeletal tissues.Innovative surgical sciences · 2026Review
- Tendon, Ligament, and Muscle Injury, Osteotendinous, Myotendinous, and Muscle-to-Bone Junction Therapy Perspectives with Growth Factors and Stable Gastric Pentadecapeptide BPC 157-A Review.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Types and doses of anti-adhesive agents injected into subacromial space do not have an effect on the clinical and anatomical outcomes after arthroscopic rotator cuff repair.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
- A Review of the Role of Tendon Stem Cells in Tendon-Bone Regeneration.Medical science monitor : international medical journal of experimental and clinical research · 2023Review
- Effectiveness of platelet-rich plasma in the treatment of Achilles tendon disease.World journal of orthopedics · 2023Article
- Investigating the histological and structural properties of tendon gel as an artificial biomaterial using the film model method in rabbits.Journal of experimental orthopaedics · 2022Article
- The Functions and Mechanisms of Basic Fibroblast Growth Factor in Tendon Repair.Frontiers in physiology · 2022Review
- Secretome from In Vitro Mechanically Loaded Myoblasts Induces Tenocyte Migration, Transition to a Fibroblastic Phenotype and Suppression of Collagen Production.International journal of molecular sciences · 2021Article
- FGF gene expression in injured tendons as a prognostic biomarker of 1-year patient outcome after Achilles tendon repair.Journal of experimental orthopaedics · 2021Article
- Article
- Tenocyte cell density, migration, and extracellular matrix deposition with amniotic suspension allograft.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
- Biomaterials in Tendon and Skeletal Muscle Tissue Engineering: Current Trends and Challenges.Materials (Basel, Switzerland) · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTendon injuries are common and it takes a long time for an injured tendon to heal. Adverse phenomena such as adhesion and rupture are associated with these injuries. Finding a method to reduce the time required for healing which improves the final outcome, will lead to decreased frequency and intensity of adverse consequences. This study was designed to investigate the effects of basic fibroblast growth factor on the healing of the Achilles tendon in rabbits.
methodsIn 10 New Zealand white rabbits, Achilles tendon was cut at the intersection of the distal and middle thirds on both hind legs. One microgram of recombinant basic fibroblast growth factor (bFGF) was injected in the proximal and distal stumps of the cut tendon on the right side (study group). Normal saline of equal volume was injected on the left side in the same way (control group). Then the tendons were repaired with 5/0 nylon using modified Kessler technique. A cast was made to immobilize each leg. On day 42, rabbits were euthanized and both hind legs were amputated. Tensometry and histopathologic examination were done on specimens.
resultsIn tensometric studies, more force was required to rupture the repair site in study group. In histopathologic examination, collagen fibers had significantly better orientation and organization in the study group. No difference was noted regarding number of fibroblast and fibrocytes, and degree of angiogenesis in the two groups.
conclusionApplication of basic fibroblast growth factor at tendon repair site improves the healing process through improvement of collagen fiber orientation and increase in biomechanical resistance.
Indexed as
Identifiers
28289610PMC5339606W2745909609What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.