ArticleWorld journal of biological chemistry2017
Biochemical changes in the injured brain.
Article in World journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Laboratory biomarkers of delayed cerebral ischemia after subarachnoid hemorrhage: a systematic review.Neurosurgical review · 2020Pooled it
- Monosodium Glutamate Treatment Elevates the Immunoreactivity of GFAP and S100β in Caudate Nucleus of the Striatum in Rats.Biomedicines · 2024Article
- Metabolic Diaschisis in Mild Traumatic Brain Injury.Journal of neurotrauma · 2024Article
- Quercetin attenuated ischemic stroke induced neurodegeneration by modulating glutamatergic and synaptic signaling pathways.Heliyon · 2024Article
- EGFR-Activated JAK2/STAT3 Pathway Confers Neuroprotection in Spinal Cord Ischemia-Reperfusion Injury: Evidence from High-Throughput Sequencing and Experimental Models.Molecular neurobiology · 2024Article
- Levels of biomarkers associated with subconcussive head hits in mixed martial arts fighters.PeerJ · 2024Article
- Memantine/Aripiprazole Combination Alleviates Cognitive Dysfunction in Valproic Acid Rat Model of Autism: Hippocampal CREB/BDNF Signaling and Glutamate Homeostasis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- Serum lactate monitoring may help to predict neurological function impairment caused by acute metabolism crisis.Scientific reports · 2023Article
- Protective effect of compatible herbs in Jin-Gu-Lian formula againstFrontiers in pharmacology · 2023Article
- Crosstalk between neurological, cardiovascular, and lifestyle disorders: insulin and lipoproteins in the lead role.Pharmacological reports : PR · 2022Review
- Neuron-Specific Enolase and S100B: The Earliest Predictors of Poor Outcome in Cardiac Arrest.Journal of clinical medicine · 2022Article
- Differential Diagnosis of Seizure and Syncope by the Means of Biochemical Markers in Emergency Department Patients.International journal of preventive medicine · 2022Article
- Serum neuron-specific enolase: A promising biomarker of silicosis.World journal of clinical cases · 2021Article
- Ameliorative Role of Cerium Oxide Nanoparticles Against Fipronil Impact on Brain Function, Oxidative Stress, and Apoptotic Cascades in Albino Rats.Frontiers in neuroscience · 2021Article
- Serum Neuron-specific Enolase and S100 Calcium-binding Protein B in Pediatric Diabetic KetoacidosisJournal of clinical research in pediatric endocrinology · 2019Article
- MicroRNA‑217 inhibition relieves cerebral ischemia/reperfusion injury by targeting SIRT1.Molecular medicine reports · 2019Article
- Advances in the Potential Biomarkers of Epilepsy.Frontiers in neurology · 2019Review
- New Insights into the Role of Neuron-Specific Enolase in Neuro-Inflammation, Neurodegeneration, and Neuroprotection.Brain sciences · 2018Review
- Identification of Proteins Differentially Expressed in the Striatum by Melatonin in a Middle Cerebral Artery Occlusion Rat Model-a Proteomic andFrontiers in neuroscience · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain metabolism is an energy intensive phenomenon involving a wide spectrum of chemical intermediaries. Various injury states have a detrimental effect on the biochemical processes involved in the homeostatic and electrophysiological properties of the brain. The biochemical markers of brain injury are a recent addition in the armamentarium of neuro-clinicians and are being increasingly used in the routine management of neuro-pathological entities such as traumatic brain injury, stroke, subarachnoid haemorrhage and intracranial space occupying lesions. These markers are increasingly being used in assessing severity as well as in predicting the prognostic course of neuro-pathological lesions. S-100 protein, neuron specific enolase, creatinine phosphokinase isoenzyme BB and myelin basic protein are some of the biochemical markers which have been proven to have prognostic and clinical value in the brain injury. While S-100, glial fibrillary acidic protein and ubiquitin C terminal hydrolase are early biomarkers of neuronal injury and have the potential to aid in clinical decision-making in the initial management of patients presenting with an acute neuronal crisis, the other biomarkers are of value in predicting long-term complications and prognosis in such patients. In recent times cerebral microdialysis has established itself as a novel way of monitoring brain tissue biochemical metabolites such as glucose, lactate, pyruvate, glutamate and glycerol while small non-coding RNAs have presented themselves as potential markers of brain injury for future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.