Evidence map›Paper›PMID 28289476›Full record

ArticleClinical epigenetics2017

DNA methylation at modifier genes of lung disease severity is altered in cystic fibrosis.

Milena Magalhães, Isabelle Rivals, Mireille Claustres, Jessica Varilh, Mélodie Thomasset, Anne Bergougnoux, Laurent Mely, Sylvie Leroy, Harriet Corvol, Loïc Guillot and 6 more

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Clinical epigenetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02884622 nacompletednot on this map

DNA Methylation and Lung Disease in Cystic Fibrosis

TypeinterventionalSponsorUniversity Hospital, MontpellierRan2013 to 2016Enrolled72ConditionsCystic FibrosisArmsnasal epithelial, Blood sampling
NCT02976714 nacompletednot on this map

Identification of Predictive Epigenetic Biomarkers of Lung Disease Severity in Cystic Fibrosis

TypeinterventionalSponsorUniversity Hospital, MontpellierRan2016 to 2021Enrolled50ConditionsCystic FibrosisArmsspontaneous sputum
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 43 citations in OpenAlex.

  1. Impact of Genetics on Endocrine Manifestations of Cystic Fibrosis.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2026
    Review
  2. Epigenetic regulation and chromatin organization in cystic fibrosis airways.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Mucosal Immunity in Cystic Fibrosis.Journal of immunology (Baltimore, Md. : 1950) · 2021
    Review
  7. Review
  8. Review
  9. Review
  10. DNA Methylation atGenes · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Methylomic correlates of autophagy activity in cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2019
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 1 country.

Milena MagalhãesLaboratoire de Génétique de Maladies Rares, EA7402 Montpellier University, Montpellier, France.
Isabelle RivalsEquipe de Statistique Appliquée-ESPCI ParisTech, PSL Research University-UMRS1158, Paris, France.
Mireille ClaustresLaboratoire de Génétique de Maladies Rares, EA7402 Montpellier University, Montpellier, France.
Jessica VarilhLaboratoire de Génétique de Maladies Rares, EA7402 Montpellier University, Montpellier, France.
Mélodie ThomassetLaboratoire de Génétique de Maladies Rares, EA7402 Montpellier University, Montpellier, France.
Anne BergougnouxLaboratoire de Génétique de Maladies Rares, EA7402 Montpellier University, Montpellier, France.
Laurent MelyCRCM, Renée Sabran Hospital-CHU Lyon, Hyères, France.
Sylvie LeroyCRCM, Pasteur Hospital-CHU Nice, Nice, France.
Harriet CorvolSorbonne Universités, UPMC Univ Paris 06, Paris, France.
Loïc GuillotSorbonne Universités, UPMC Univ Paris 06, Paris, France.
Marlène MurrisCRCM, Larrey Hospital-CHU Toulouse, Toulouse, France.
Emmanuelle BeyneLaboratoire de Génétique de Maladies Rares, EA7402 Montpellier University, Montpellier, France.
Davide CaimmiCRCM, Arnaud de Villeneuve Hospital-CHU Montpellier, Montpellier, France.
Isabelle VachierCRCM, Arnaud de Villeneuve Hospital-CHU Montpellier, Montpellier, France.
Raphaël ChironCRCM, Arnaud de Villeneuve Hospital-CHU Montpellier, Montpellier, France.
Albertina De SarioLaboratoire de Génétique de Maladies Rares, EA7402 Montpellier University, Montpellier, France.ORCID 0000-0002-9997-1645
Université de Montpellier · FRHôpital Arnaud de Villeneuve · FRInserm · FRHôpital Larrey · FRHôpital Pasteur · FRHôpital Renée Sabran · FRParisTech · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLung disease progression is variable among cystic fibrosis (CF) patients and depends on DNA mutations in the

resultsWe profiled DNA methylation at

conclusionsDNA methylation levels are altered in nasal epithelial and blood cell samples from CF patients. Analysis of

Indexed as

DNA MethylationGenes, ModifierAdultCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorEpigenomicsFemaleGlutathione TransferaseHeme Oxygenase-1HumansLung DiseasesMaleNoseReceptor, Endothelin ASequence Analysis, DNASequence DeletionCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorGlutathione TransferaseGSTM3 protein, humanHeme Oxygenase-1HMOX1 protein, humanReceptor, Endothelin ACo-methylationCystic fibrosisDNA methylationModifier geneNasal epithelial cellsNext-generation sequencingPolymorphismPulmonary functionPyrosequencing

Identifiers

PMID28289476
PMCPMC5310067
OpenAlexW2588296085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.