ArticleJournal of biological engineering2017
Detection of extremely low concentration waterborne pathogen using a multiplexing self-referencing SERS microfluidic biosensor.
Article in Journal of biological engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 88 citations in OpenAlex.
- Conditional superiorities and unaddressed bottlenecks: a critical review of artificial intelligence for waterborne microbial detection.Applied microbiology and biotechnology · 2026Review
- Surface-enhanced Raman spectroscopy combined microfluidic analytical devices for on-site food safety analysis.Mikrochimica acta · 2026Review
- Recent developments in waterborne pathogen detection technologies.Environmental monitoring and assessment · 2025Review
- Lab-on-a-Chip Devices for Nucleic Acid Analysis in Food Safety.Micromachines · 2024Review
- Machine Learning-Assisted Surface-Enhanced Raman Spectroscopy Detection for Environmental Applications: A Review.Environmental science & technology · 2024Review
- Advancing SERS as a quantitative technique: challenges, considerations, and correlative approaches to aid validation.Nano convergence · 2024Review
- Surface Functionalization andBiosensors · 2023Article
- Application of SERS in the Detection of Fungi, Bacteria and Viruses.Nanomaterials (Basel, Switzerland) · 2022Review
- Label-Free Differentiation of Cancer and Non-Cancer Cells Based on Machine-Learning-Algorithm-Assisted Fast Raman Imaging.Biosensors · 2022Article
- Separation and detection of E. coli O157:H7 using a SERS-based microfluidic immunosensor.Mikrochimica acta · 2022Article
- Nanotechnology in food and water security: on-site detection of agricultural pollutants through surface-enhanced Raman spectroscopy.Emergent materials · 2022Review
- Machine learning-assisted ammonium detection using zinc oxide/multi-walled carbon nanotube composite based impedance sensors.Scientific reports · 2021Article
- Raman Scattering-Based Biosensing: New Prospects and Opportunities.Biosensors · 2021Review
- Surface enhanced Raman scattering for the multiplexed detection of pathogenic microorganisms: towards point-of-use applications.The Analyst · 2021Review
- Recent Advances in Electrochemical Biosensors: Applications, Challenges, and Future Scope.Biosensors · 2021Review
- Application of Raman Spectroscopic Methods in Food Safety: A Review.Biosensors · 2021Review
- Ozonation enhancement of low cost double-stranded DNA binding dye based fluorescence measurement of total bacterial load in water.RSC advances · 2021Article
- A Dual Immunological Raman-Enabled Crosschecking Test (DIRECT) for Detection of Bacteria in Low Moisture Food.Biosensors · 2020Article
- Microfluidic-Based Approaches for Foodborne Pathogen Detection.Microorganisms · 2019Review
- High purity and viability cell separation of a bacterivorous jakobid flagellate based on a steep velocity gradient induced soft inertial force.RSC advances · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is challenging to achieve ultrasensitive and selective detection of waterborne pathogens at extremely low levels (i.e., single cell/mL) using conventional methods. Even with molecular methods such as ELISA or PCR, multi-enrichment steps are needed which are labor and cost intensive. In this study, we incorporated nano-dielectrophoretic microfluidic device with Surface enhanced Raman scattering (SERS) technique to build a novel portable biosensor for easy detection and characterization of
resultsA multiplexing dual recognition SERS scheme was developed to achieve one-step target detection without the need to separate target-bound probes from unbound ones. With three different SERS-tagged molecular probes targeting different epitopes of the same pathogen being deployed simultaneously, detection of pathogen targets was achieved at single cell level with sub-species specificity that has not been reported before in single-step pathogen detection.
conclusionThe self-referencing protocol implements with a Nano-dielectrophoretic microfluidic device potentially can become an easy-to-use, field-deployable spectroscopic sensor for onsite detection of pathogenic microorganisms.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.