Evidence map›Paper›PMID 28289409›Full record

ArticleFrontiers in immunology2017

Mitochondrial DNA Activates the NLRP3 Inflammasome and Predisposes to Type 1 Diabetes in Murine Model.

Daniela Carlos, Frederico R C Costa, Camila A Pereira, Fernanda A Rocha, Juliana N U Yaochite, Gabriela G Oliveira, Fernando S Carneiro, Rita C Tostes, Simone G Ramos, Dario S Zamboni and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 105 citations in OpenAlex.

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  13. The role of regulated necrosis in diabetes and its complications.Journal of molecular medicine (Berlin, Germany) · 2024
    Review
  14. Review
  15. Canonical and non-canonical functions of NLRP3.Journal of advanced research · 2023
    Review
  16. Review
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  18. Dysfunctions, molecular mechanisms, and therapeutic strategies of pancreatic β-cells in diabetes.Apoptosis : an international journal on programmed cell death · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 3 countries.

Daniela CarlosDepartment of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo , Ribeirao Preto , Brazil.
Frederico R C CostaDepartment of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo , Ribeirao Preto , Brazil.
Camila A PereiraDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo , Ribeirao Preto , Brazil.
Fernanda A RochaDepartment of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo , Ribeirao Preto , Brazil.
Juliana N U YaochiteDepartment of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo , Ribeirao Preto , Brazil.
Gabriela G OliveiraDepartment of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo , Ribeirao Preto , Brazil.
Fernando S CarneiroDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo , Ribeirao Preto , Brazil.
Rita C TostesDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo , Ribeirao Preto , Brazil.
Simone G RamosDepartment of Pathology and Legal Medicine, Ribeirão Preto Medical School, University of São Paulo , Ribeirao Preto , Brazil.
Dario S ZamboniDepartment of Molecular and Cell Biology, Ribeirão Preto Medical School, University of São Paulo , Ribeirao Preto , Brazil.
Niels O S CamaraDepartment of Immunology, Institute of Biomedical Sciences (ICB), University of São Paulo , São Paulo , Brazil.
Bernhard RyffelUniversity of Orleans and CNRS, INEM, Molecular Immunology, UMR6218, Orleans, France; IDM, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
João S SilvaDepartment of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo , Ribeirao Preto , Brazil.
Universidade de São Paulo · BRImmunologie et Neurogénétique Expérimentales et Moléculaires · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although a correlation between polymorphisms of NOD-like receptor family-pyrin domain containing 3 (NLRP3) and predisposition to type 1 diabetes (T1D) has been identified, the potential function and activation of the NLRP3 inflammasome in T1D have not been clarified. The present study shows that non-obese diabetic mice exhibited increased NLRP3, and pro-IL-1β gene expression in pancreatic lymph nodes (PLNs). Similar increases in gene expression of NLRP3, apoptosis associated speck like protein (ASC) and pro-IL-1β were induced by multiple low doses of streptozotocin (STZ) in C57BL/6 mice. In addition, diabetic C57BL/6 mice also exhibited increased IL-1β protein expression in the pancreatic tissue at day 7, which remained elevated until day 15. Diabetic mice also showed increased positive caspase-1 macrophages in the PLNs, which were decreased in NLRP3

Indexed as

cytokinesIFNγ-producing CD4 T cells (Th1)IFNγ-producing CD8 T cells (Tc1)IL-17-producing CD4 T cells (Th17)IL-17-producing CD8 T cells (Tc17)NLRP3 inflammasometype 1 diabetes

Identifiers

PMID28289409
PMCPMC5326761
OpenAlexW2591054359

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.