ReviewFrontiers in neurology2017
Sleep Disorders: Is the Trigemino-Cardiac Reflex a Missing Link?
Review in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- The association between allergic rhinitis and sleep: A systematic review and meta-analysis of observational studies.PloS one · 2020Pooled it
- Exploring the trigeminocardiac reflex: an integrated view from mechanism to clinic.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Review
- The Effect of Cadmium on Sleep Parameters Assessed in Polysomnographic Studies: A Case-Control Study.Journal of clinical medicine · 2023Article
- Brain-derived neurotrophic factor in relation to central obesity in children with sleep disordered breathing.Archives of medical science : AMS · 2021Article
- Predictor of sleep difficulty among community dwelling older populations in 2 African settings.Medicine · 2019Article
- The Bruxoff Device as a Screening Method for Sleep Bruxism in Dental Practice.Journal of clinical medicine · 2019Article
- Chewing-induced asystole: a manifestation of the trigeminal cardiac reflex in stroke recovery.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Article
- Grinding to a halt: Stimulation of the trigeminal cardiac reflex from severe bruxism.HeartRhythm case reports · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trigeminal innervated areas in face, nasolacrimal, and nasal mucosa can produce a wide array of cardiorespiratory manifestations that include apnea, bradypnea, bradycardia, hypotension, and arrhythmias. This reflex is a well-known entity called "trigemino-cardiac reflex" (TCR). The role of TCR is investigated in various pathophysiological conditions especially in neurosurgical, but also skull base surgery procedures. Additionally, its significance in various sleep-related disorders has also been highlighted recently. Though, the role of diving reflex, a subtype of TCR, has been extensively investigated in sudden infant death syndrome. The data related to other sleep disorders including obstructive sleep apnea, bruxism is very limited and thus, this mini review aims to investigate the possible role and correlation of TCR in causing such sleep abnormalities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.