Evidence map›Paper›PMID 28289216›Full record

Trial reportProceedings of the National Academy of Sciences of the United States of America2017

B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial.

Jia Zhong, Oskar Karlsson, Guan Wang, Jun Li, Yichen Guo, Xinyi Lin, Michele Zemplenyi, Marco Sanchez-Guerra, Letizia Trevisi, Bruce Urch and 8 more

Erratum issued Registry-linked trialOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01864824 (Air Pollution, Epigenetics and Cardiovascular Health), which is not on this map. Cited by 73 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 1 pooled it
8.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01864824 phase1completednot on this map

Air Pollution, Epigenetics and Cardiovascular Health: A Human Intervention Trial

TypeinterventionalSponsorHarvard School of Public Health (HSPH)Ran2013 to 2014Enrolled10ConditionsHeart Rate, Heart Rate Variability, InflammationArmsmethyl donor, Placebo
3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 1 synthesis or guideline pooled it, 148 citations in OpenAlex.

  1. Pooled it
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  16. The Effect of Wildfires on Asthma and Allergies.The journal of allergy and clinical immunology. In practice · 2025
    Review
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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 6 countries.

Jia ZhongMailman School of Public Health, Columbia University, New York, NY 10032; jiazhong@mail.harvard.edu.ORCID 0000-0003-4582-6896
Oskar KarlssonCenter for Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.
Guan WangInstitute for Genomic Medicine, Columbia University, New York, NY 10032.
Jun LiDepartment of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, 430030.
Yichen GuoDepartment of Biostatistics, T. H. Chan School of Public Health, Harvard University, Boston, MA 02115.
Xinyi LinSingapore Institute for Clinical Sciences, Singapore 117609.
Michele ZemplenyiDepartment of Biostatistics, T. H. Chan School of Public Health, Harvard University, Boston, MA 02115.
Marco Sanchez-GuerraDepartment of Developmental Neurobiology, National Institute of Perinatology, Mexico City 11000, Mexico.
Letizia TrevisiDepartment of Environmental Health, T. H. Chan School of Public Health, Harvard University, Boston, MA 02115.
Bruce UrchDivision of Occupational & Environmental Health, Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada.
Mary SpeckDivision of Occupational & Environmental Health, Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada.
Liming LiangDepartment of Biostatistics, T. H. Chan School of Public Health, Harvard University, Boston, MA 02115.
Brent A CoullDepartment of Biostatistics, T. H. Chan School of Public Health, Harvard University, Boston, MA 02115.
Petros KoutrakisDepartment of Environmental Health, T. H. Chan School of Public Health, Harvard University, Boston, MA 02115.
Frances SilvermanDivision of Occupational & Environmental Health, Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada.
Diane R GoldDepartment of Environmental Health, T. H. Chan School of Public Health, Harvard University, Boston, MA 02115.
Tangchun WuDepartment of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, 430030.
Andrea A BaccarelliMailman School of Public Health, Columbia University, New York, NY 10032.
Harvard University · USColumbia University · USHuazhong University of Science and Technology · CNSt. Michael's Hospital · CABrigham and Women's Hospital · USInstituto Nacional de Perinatología · MXSingapore Institute for Clinical Sciences · SGUniversity of Toronto · CAUppsala University · SE

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
Epigenetic Effects of Particles and Metals on Cardiac Health of an Aging CohortR01ES015172 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI SCHWARTZ, JOEL D · 2006 to 2015
$4.8M
BPA, Phthalates & Stress: Mechanisms and Interactions for Childhood ObesityR01ES021357 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA, WRIGHT, ROBERT O · 2012 to 2016
$3.3M
Epigenetic Mechanisms of PM-Mediated CVD RiskR01ES020836 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BACCARELLI, ANDREA, HOU, LIFANG · 2012 to 2016
$3.0M
Molecular and Epigenetic Mitochondriomics of Air Particles, Lead and CognitionR01ES021733 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA · 2012 to 2015
$2.4M
Air Pollution, Epigenetics and Cardiovascular Health: A Human Intervention TrialR21ES021895 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA · 2012 to 2013
$376k
NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30 ES009089NIEHS NIH HHS R01 ES015172NIEHS NIH HHS R01 ES020836NIEHS NIH HHS R01 ES021357NIEHS NIH HHS R01 ES021733NIEHS NIH HHS R21 ES021895
6 · The paper itself

Abstract

Acute exposure to fine particle (PM

Indexed as

AdolescentAdultAir PollutantsAir PollutionCross-Over StudiesDNA MethylationDNA, MitochondrialEpigenesis, GeneticEpigenomicsFemaleFolic AcidHumansMaleParticulate MatterPilot ProjectsT-Lymphocytes, Helper-InducerAir PollutantsDNA, MitochondrialFolic AcidParticulate MatterVitamin B 12Vitamin B 6air pollutionB vitaminsDNA methylationmitochondria

Identifiers

PMID28289216
PMCPMC5380085
OpenAlexW2596362505

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.