Trial reportProceedings of the National Academy of Sciences of the United States of America2017
Selective dietary supplementation in early postpartum is associated with high resilience against depressed mood.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03296956 (A Dietary Supplement for Mood Symptoms in Early Postpartum), which is not on this map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Dietary Supplement for Mood Symptoms in Early Postpartum: A Double Blind Randomized Placebo Controlled Trial
Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Mental Health in New Mothers: A Randomised Controlled Study into the Effects of Dietary Flavonoids on Mood and Perceived Quality of Life.Nutrients · 2021Trial
- Article
- Addressing Mental Health in Rural Settings: A Narrative Review of Blueberry Supplementation as a Natural Intervention.Nutrients · 2024Review
- Dietary supplement for mood symptoms in early postpartum: a double-blind randomized placebo controlled trial.EClinicalMedicine · 2024Article
- The effects of flavonoid supplementation on the mental health of postpartum parents.Frontiers in global women's health · 2024Article
- A Probiotic Intervention With Bifidobacterium longum NCC3001 on Perinatal Mood Outcomes (PROMOTE Study): Protocol for a Decentralized Randomized Controlled Trial.JMIR research protocols · 2023Article
- Increased fruit intake is associated with reduced risk of depression: evidence from cross-sectional and Mendelian randomization analyses.Frontiers in public health · 2023Article
- Article
- Promising leads and pitfalls: a review of dietary supplements and hormone treatments to prevent postpartum blues and postpartum depression.Archives of women's mental health · 2021Review
- Pharmacological sex hormone manipulation as a risk model for depression.Journal of neuroscience research · 2020Review
- Stress, sex hormones, inflammation, and major depressive disorder: Extending Social Signal Transduction Theory of Depression to account for sex differences in mood disorders.Psychopharmacology · 2019Review
- Depressed mood induction in early cigarette withdrawal is unaffected by acute monoamine precursor supplementation.Neuropsychiatric disease and treatment · 2019Article
- Differential expression of IL-6/IL-6R and MAO-A regulates invasion/angiogenesis in breast cancer.British journal of cancer · 2018Article
- Novel urinary metabolite signature for diagnosing postpartum depression.Neuropsychiatric disease and treatment · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Medical research is moving toward prevention strategies during prodromal states. Postpartum blues (PPB) is often a prodromal state for postpartum depression (PPD), with severe PPB strongly associated with an elevated risk for PPD. The most common complication of childbearing, PPD has a prevalence of 13%, but there are no widespread prevention strategies, and no nutraceutical interventions have been developed. To counter the effects of the 40% increase in monoamine oxidase A (MAO-A) levels that occurs during PPB, a dietary supplement kit consisting of monoamine precursor amino acids and dietary antioxidants was created. Key ingredients (tryptophan and tyrosine) were shown not to affect their total concentration in breast milk. The aim of this open-label study was to assess whether this dietary supplement reduces vulnerability to depressed mood at postpartum day 5, the typical peak of PPB. Forty-one healthy women completed all study procedures. One group (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.