ArticleProceedings of the National Academy of Sciences of the United States of America2017
Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism.
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In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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0cells of the map it votes in
23citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
What it found
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Structural analysis of rhodopsin states in megabody complexes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Small-Molecule Ligands of Rhodopsin and Their Therapeutic Potential in Retina Degeneration.International journal of molecular sciences · 2025Review
- Advances and therapeutic opportunities in visual cycle modulation.Progress in retinal and eye research · 2025Review
- Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways.Nature communications · 2025Article
- Activating an invertebrate bistable opsin with the all-trans 6.11 retinal analog.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Theoretical study on the structure, spectroscopic, and current-voltage behavior of 11-Cis and Trans retinal isomers in rhodopsin.Scientific reports · 2024Article
- A short story on how chromophore is hydrolyzed from rhodopsin for recycling.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023Review
- Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain.Nature communications · 2023Article
- Dynamic lipid turnover in photoreceptors and retinal pigment epithelium throughout life.Progress in retinal and eye research · 2022Review
- Article
- Rhodopsins: An Excitingly Versatile Protein Species for Research, Development and Creative Engineering.Frontiers in chemistry · 2022Review
- Structural aspects of rod opsin and their implication in genetic diseases.Pflugers Archiv : European journal of physiology · 2021Review
- Stereospecific modulation of dimeric rhodopsin.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- A benchmark study of loop modeling methods applied to G protein-coupled receptors.Journal of computer-aided molecular design · 2019Article
- Specificity of the chromophore-binding site in human cone opsins.The Journal of biological chemistry · 2019Article
- Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases.Science advances · 2019Article
- Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration.Molecular pharmacology · 2018Article
- Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor.Nature communications · 2018Article
- A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration.Nature communications · 2018Article
- Retinal-chitosan Conjugates Effectively Deliver Active Chromophores to Retinal Photoreceptor Cells in Blind Mice and Dogs.Molecular pharmacology · 2018Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Sahil GulatiDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.
Beata JastrzebskaDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.
Surajit BanerjeeDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14850.
Ángel L PlaceresDepartment of Chemistry, Case Western Reserve University, Cleveland, OH 44106.
Przemyslaw MisztaFaculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, 00-927 Warsaw, Poland.
Songqi GaoDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.
Karl GundersonNovartis Institutes for BioMedical Research, Cambridge, MA 02139.
Gregory P TochtropDepartment of Chemistry, Case Western Reserve University, Cleveland, OH 44106.
Sławomir FilipekFaculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, 00-927 Warsaw, Poland.ORCID 0000-0003-3147-3858
Kota KatayamaDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106; kxk477@case.edu kxp65@case.edu.
Philip D KiserDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.ORCID 0000-0003-1184-9539
Muneto MogiNovartis Institutes for BioMedical Research, Cambridge, MA 02139.
Phoebe L StewartDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.
Krzysztof PalczewskiDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106; kxk477@case.edu kxp65@case.edu.ORCID 0000-0002-0788-545X
Case Western Reserve University · USUniversity of Warsaw · PLArgonne National Laboratory · USLouis Stokes Cleveland VA Medical Center · US
Funding
Overall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3MPharmacological Treatment of Retinal DiseasesR24EY021126 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI PALCZEWSKI, KRZYSZTOF · 2010 to 2014
$12.8MUse of systems pharmacology to prevent rod and cone photoreceptor degenerationR24EY027283 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI PALCZEWSKI, KRZYSZTOF · 2017 to 2021
$7.9MPixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8MNon-hydrolysable analogs of retinal chromophore; potential new therapeutics to prevent retinal degenerationR01EY025214 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI JASTRZEBSKA, BEATA · 2016 to 2020
$1.8MTriterpenoid Modulators of Inflammatory Driven CarcinogenesisR01CA157735 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI TOCHTROP, GREGORY P · 2011 to 2015
$1.5MStudies on visual cycles and their relevance to age-related macular degenerationIK2BX002683 · VA · VETERANS HEALTH ADMINISTRATION · PI KISER, PHILIP DAVID · 2015 to 2019
–BLRD VA IK2 BX002683NCI NIH HHS R01 CA157735NCRR NIH HHS S10 RR029205NEI NIH HHS R01 EY025214NEI NIH HHS R24 EY021126NEI NIH HHS R24 EY027283NIGMS NIH HHS P41 GM103403
Abstract
Vertebrate rhodopsin (Rh) contains 11-
Indexed as
AnimalsCattleChromatography, High Pressure LiquidIsomerismPhotochemical ProcessesRhodopsinRhodopsinchromophoreGPCRisomerizationrhodopsinvision
Identifiers
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Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.