Evidence map›Paper›PMID 28289184›Full record

ArticleJournal of the American Society of Nephrology : JASN2017

Renal Tubular Ubiquitin-Protein Ligase NEDD4-2 Is Required for Renal Adaptation during Long-Term Potassium Depletion.

Lama Al-Qusairi, Denis Basquin, Ankita Roy, Renuga Devi Rajaram, Marc P Maillard, Arohan R Subramanya, Olivier Staub

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Renal tubular SGK1 is required to achieve blood pressure surge and circadian rhythm.American journal of physiology. Renal physiology · 2023
    Article
  7. Review
  8. UBR5 is a novel regulator of WNK1 stability.American journal of physiology. Cell physiology · 2022
    Article
  9. Article
  10. Article
  11. WNK1 in Malignant Behaviors: A Potential Target for Cancer?Frontiers in cell and developmental biology · 2022
    Review
  12. Article
  13. Deletion of renal Nedd4-2 abolishes the effect of high KAmerican journal of physiology. Renal physiology · 2021
    Article
  14. Article
  15. Article
  16. Greater natriuretic response to ENaC inhibition in male versus female Sprague-Dawley rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2020
    Article
  17. WNK bodies cluster WNK4 and SPAK/OSR1 to promote NCC activation in hypokalemia.American journal of physiology. Renal physiology · 2020
    Article
  18. MgAmerican journal of physiology. Renal physiology · 2019
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Lama Al-QusairiDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
Denis BasquinDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
Ankita RoyDepartment of Medicine, University of Pittsburgh School of Medicine and VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania; and.
Renuga Devi RajaramDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
Marc P MaillardService of Nephrology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Arohan R SubramanyaDepartment of Medicine, University of Pittsburgh School of Medicine and VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania; and olivier.staub@unil.ch ars129@pitt.edu.
Olivier StaubDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland; olivier.staub@unil.ch ars129@pitt.edu.
University of Lausanne · CHUniversity of Pittsburgh · USUniversity Hospital of Lausanne · CH

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Control of the Renal WNK Signaling Pathway by Phase TransitionsR01DK098145 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AYLIN RACHEL RODAN, AROHAN R SUBRAMANYA · 2014 to 2026
$4.2M
NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK098145
6 · The paper itself

Abstract

Adaptation of the organism to potassium (K

Indexed as

Adaptation, PhysiologicalAnimalsEndosomal Sorting Complexes Required for TransportHypokalemiaKidneyKidney Tubules, DistalMiceNedd4 Ubiquitin Protein LigasesTime FactorsUbiquitin-Protein LigasesEndosomal Sorting Complexes Required for TransportNedd4l protein, mouseNedd4 Ubiquitin Protein LigasesUbiquitin-Protein LigasesENaCion transportK channelssignaling

Identifiers

PMID28289184
PMCPMC5533229
OpenAlexW2595380400

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.