ArticleGenes & development2017
Transcription factor Wilms' tumor 1 regulates developmental RNAs through 3' UTR interaction.
Article in Genes & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Systematic mapping of small nucleolar RNA interactions in human cells.RNA biology · 2025Article
- Upregulation of HOXA3 by isoform-specific Wilms tumour 1 drives chemotherapy resistance in acute myeloid leukaemia.British journal of haematology · 2024Article
- Control of endothelial cell function and arteriogenesis by MEG3:EZH2 epigenetic regulation of integrin expression.Molecular therapy. Nucleic acids · 2024Article
- Endothelial deletion of Wt1 disrupts coronary angiogenesis and myocardium development.Development (Cambridge, England) · 2023Article
- Alteration in DNA-binding affinity of Wilms tumor 1 protein due to WT1 genetic variants associated with steroid - resistant nephrotic syndrome in children.Scientific reports · 2022Article
- The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor.Molecular oncology · 2022Article
- Editorial: WT1 in Development and Disease.Frontiers in cell and developmental biology · 2022Article
- A NovelBiology · 2021Article
- Implications of the Wilms' Tumor Suppressor Wt1 in Cardiomyocyte Differentiation.International journal of molecular sciences · 2021Article
- Resolving the heterogeneity of diaphragmatic mesenchyme: a novel mouse model of congenital diaphragmatic hernia.Disease models & mechanisms · 2021Article
- An Unbiased Molecular Approach Using 3'-UTRs Resolves the Avian Family-Level Tree of Life.Molecular biology and evolution · 2021Article
- Data on changes in renal calyceal pattern among renal donors using CT angiography.Bioinformation · 2021Article
- Article
- A 17-bp InDel (rs668420586) within goat3 Biotech · 2020Article
- A role for SOX9 in post-transcriptional processes: insights from the amphibian oocyte.Scientific reports · 2018Article
- Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites.Nucleic acids research · 2018Article
- Beyond Transcription: Roles of Transcription Factors in Pre-mRNA Splicing.Chemical reviews · 2018Review
- Activation of podocyte Notch mediates early Wt1 glomerulopathy.Kidney international · 2018Article
- Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Wilms' tumor 1 (WT1) is essential for the development and homeostasis of multiple mesodermal tissues. Despite evidence for post-transcriptional roles, no endogenous WT1 target RNAs exist. Using RNA immunoprecipitation and UV cross-linking, we show that WT1 binds preferentially to 3' untranslated regions (UTRs) of developmental targets. These target mRNAs are down-regulated upon WT1 depletion in cell culture and developing kidney mesenchyme.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.