Evidence map›Paper›PMID 28289130›Full record

ArticleDevelopment (Cambridge, England)2017

Inhibition of ectopic microtubule assembly by the kinesin-13 KLP-7 prevents chromosome segregation and cytokinesis defects in oocytes.

Emmanuelle Gigant, Marine Stefanutti, Kimberley Laband, Agata Gluszek-Kustusz, Frances Edwards, Benjamin Lacroix, Gilliane Maton, Julie C Canman, Julie P I Welburn, Julien Dumont

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 56 citations in OpenAlex.

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  7. Polo-like kinase 1 prevents excess microtubule polymerization inbioRxiv : the preprint server for biology · 2024
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  14. Cortical microtubules oppose actomyosin-driven membrane ingression duringbioRxiv : the preprint server for biology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Emmanuelle GigantInstitut Jacques Monod, CNRS, UMR 7592, University Paris Diderot, Sorbonne Paris Cité, Paris F-75205, France.ORCID 0000-0001-9098-0994
Marine StefanuttiInstitut Jacques Monod, CNRS, UMR 7592, University Paris Diderot, Sorbonne Paris Cité, Paris F-75205, France.
Kimberley LabandInstitut Jacques Monod, CNRS, UMR 7592, University Paris Diderot, Sorbonne Paris Cité, Paris F-75205, France.
Agata Gluszek-KustuszWellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JR, Scotland, UK.
Frances EdwardsInstitut Jacques Monod, CNRS, UMR 7592, University Paris Diderot, Sorbonne Paris Cité, Paris F-75205, France.
Benjamin LacroixInstitut Jacques Monod, CNRS, UMR 7592, University Paris Diderot, Sorbonne Paris Cité, Paris F-75205, France.
Gilliane MatonInstitut Jacques Monod, CNRS, UMR 7592, University Paris Diderot, Sorbonne Paris Cité, Paris F-75205, France.
Julie C CanmanColumbia University, Department of Pathology and Cell Biology, New York, NY 10032, USA.
Julie P I WelburnWellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JR, Scotland, UK.
Julien DumontInstitut Jacques Monod, CNRS, UMR 7592, University Paris Diderot, Sorbonne Paris Cité, Paris F-75205, France julien.dumont@ijm.fr.ORCID 0000-0001-5312-9770
Centre National de la Recherche Scientifique · FRWellcome Centre for Cell Biology · GBColumbia University · US

Funding

Cell type-variation of cytokinesisR01GM117407 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CANMAN, JULIE C · 2016 to 2023
$2.9M
IR-LAMP: Optigenetic technology to spatially manipulate protein function in vivoDP2OD008773 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CANMAN, JULIE C · 2011 to 2011
$2.4M
NIGMS NIH HHS R01 GM117407NIH HHS DP2 OD008773
6 · The paper itself

Abstract

In most species, oocytes lack centrosomes. Accurate meiotic spindle assembly and chromosome segregation - essential to prevent miscarriage or developmental defects - thus occur through atypical mechanisms that are not well characterized. Using quantitative

Indexed as

Chromosome SegregationCytokinesisCaenorhabditis elegans ProteinsHeLa CellsHumansImaging, Three-DimensionalKinesinsMeiosisMicrotubulesOocytesSpindle ApparatusCaenorhabditis elegans ProteinsKinesinsklp-7 protein, C elegansChromosome segregationCytoskeletonMeiotic spindleMicrotubule depolymeraseMicrotubule dynamicsPolar body extrusion

Identifiers

PMID28289130
PMCPMC5450848
OpenAlexW2597278283

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.