Evidence map›Paper›PMID 28289088›Full record

ArticleEuropean journal of endocrinology2017

Association between neuroendocrine tumors biomarkers and primary tumor site and disease type based on total

Amit Tirosh, Georgios Z Papadakis, Corina Millo, Samira M Sadowski, Peter Herscovitch, Karel Pacak, Stephen J Marx, Lily Yang, Pavel Nockel, Jasmine Shell and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in European journal of endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Frontiers in endocrinology · 2026
    Article
  3. Article
  4. [Cancers · 2025
    Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. PET/CT and PET/MRI in ophthalmic oncology (Review).International journal of oncology · 2020
    Review
  15. Review
  16. Prognostic value of somatostatin receptor expressing tumor volume calculated fromEuropean journal of nuclear medicine and molecular imaging · 2019
    Article
  17. Review
  18. Management of Gastrointestinal Neuroendocrine Tumors.Clinical medicine insights. Endocrinology and diabetes · 2019
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 4 countries.

Amit TiroshSection on Medical NeuroendocrinologyEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Georgios Z PapadakisPET-DepartmentNational Institutes of Health Clinical Center, Bethesda, Maryland, USA.
Corina MilloPET-DepartmentNational Institutes of Health Clinical Center, Bethesda, Maryland, USA.
Samira M SadowskiEndocrine and Thoracic SurgeryUniversity Hospitals of Geneva, Geneva, Switzerland.
Peter HerscovitchPET-DepartmentNational Institutes of Health Clinical Center, Bethesda, Maryland, USA.
Karel PacakSection on Medical NeuroendocrinologyEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Stephen J MarxSection on Medical NeuroendocrinologyEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Lily YangEndocrine Oncology BranchNational Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Pavel NockelEndocrine Oncology BranchNational Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Jasmine ShellEndocrine Oncology BranchNational Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Patience GreenEndocrine Oncology BranchNational Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Xavier M KeutgenEndocrine Oncology BranchNational Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Dhaval PatelEndocrine Oncology BranchNational Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Naris NilubolEndocrine Oncology BranchNational Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Electron KebebewEndocrine Oncology BranchNational Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
National Institutes of Health · USNational Cancer Institute · USNational Institutes of Health Clinical Center · USFoundation for Research and Technology Hellas · GRGeneva College · USGeorge Washington University · US

Funding

Diagnosis, Pathophysiology And Molecular Biology of Pheochromocytoma and ParagangliomaZIAHD008735 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI PACAK, KAREL · 2009 to 2024
$28.4M
Genomic and genetic studies of endocrine cancersZIABC011275 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KEBEBEW, ELECTRON · 2010 to 2018
$8.2M
EOB Clinical CoreZIDBC011534 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KEBEBEW, ELECTRON · 2014 to 2018
$4.8M
EOB Clinical and Research Fellowship Training ProgramZIEBC011656 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KEBEBEW, ELECTRON · 2015 to 2018
$3.7M
Intramural NIH HHS ZIA BC011275Intramural NIH HHS ZID BC011534Intramural NIH HHS ZIE BC011656
6 · The paper itself

Abstract

objectiveTo determine the association between neuroendocrine tumor (NET) biomarker levels and the extent of disease as assessed by

designA retrospective analysis of a prospective database of patients with NETs.

methodsFasting plasma chromogranin A (CgA), neuron-specific enolase (NSE), gastrin, glucagon, vasoactive intestinal peptide (VIP) and pancreatic polypeptide (PP), and 24-h urinary 5-hydroxyindoleacetic acid (5-HIAA) levels were measured. Correlation between biomarkers and total

resultsThe analysis included 232 patients. In patients with pancreatic NETs (

conclusionsOur data supports the use of specific NET biomarkers based on the site of the primary NET and the presence of hereditary syndrome-associated NET. High urinary 5-HIAA levels indicate the presence of metastatic disease in patients with SINET.

Indexed as

AdultBiomarkers, TumorCohort StudiesDatabases, FactualFemaleHumansHydroxyindoleacetic AcidMagnetic Resonance ImagingMaleMultimodal ImagingMultiple Endocrine NeoplasiaNeoplasm MetastasisNeuroendocrine TumorsOrganometallic CompoundsPancreatic NeoplasmsPositron-Emission TomographyBiomarkers, Tumorgallium Ga 68 dotatateHydroxyindoleacetic AcidOrganometallic CompoundsRadiopharmaceuticals

Identifiers

PMID28289088
PMCPMC5430160
OpenAlexW2595802089

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.