ArticleJournal of the American Heart Association2017
Bone Mineral Density and Risk of Heart Failure in Older Adults: The Cardiovascular Health Study.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Bone mineral density in patients with chronic heart failure: a meta-analysis.Clinical interventions in aging · 2018Pooled it
- Underlying Mechanisms of Osteoporosis in the Context of Multimorbidity: Clinical Challenges and Management Strategies.Nutrients · 2026Review
- Low skeletal muscle index combined with reduced bone density increases mortality rate in older adults with heart failure.Aging clinical and experimental research · 2025Article
- Characterizing the Lipid Profile in Patients with Vertebral or Hip Fragility Fractures: A Hospital-Based Descriptive Study.Journal of clinical medicine · 2025Article
- The link between osteoporosis and cardiovascular diseases: a review of shared mechanisms, risk factors, and therapeutic approaches.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Review
- Bone mineral density and cardiovascular diseases: a two-sample Mendelian randomization study.JBMR plus · 2025Article
- MLO-Y4 fluid flow shear stress conditioned media enhances cardiac contractility and intracellular CaAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- The potential protective role of vitamin D and calcium supplements in reducing cardiovascular disease risk among elderly patients with osteopenia.Irish journal of medical science · 2024Article
- Vitamin D Deficiency and Cardiovascular Mortality: Retrospective Analysis "Siena Osteoporosis" Cohort.Nutrients · 2023Article
- Sex- and race-specific associations of bone mineral density with incident heart failure and its subtypes in older adults.Journal of the American Geriatrics Society · 2023Article
- Association between bone mineral density and cardiovascular disease in older adults.Frontiers in public health · 2023Article
- Risk of earlier atherosclerotic cardiovascular disease in women with low bone mineral density.Scientific reports · 2022Article
- A negative association between total cholesterol and bone mineral density in US adult women.Frontiers in nutrition · 2022Article
- Impact of heart failure severity on bone mineral density among older patients with heart failure.Heart and vessels · 2021Article
- Bone mineral density and risk of cardiovascular disease in men and women: the HUNT study.European journal of epidemiology · 2021Article
- Cardiovascular Safety of Antifracture Medications in Patients With Osteoporosis: A Narrative Review of Evidence From Randomized Studies.JBMR plus · 2021Review
- Bone in heart failure.Journal of cachexia, sarcopenia and muscle · 2020Review
- FAM210A is a novel determinant of bone and muscle structure and strength.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Bone mineral density in older patients with chronic heart failure is related to NYHA classification: a retrospective study.European geriatric medicine · 2018Article
- Walking balance is mediated by muscle strength and bone mineral density in postmenopausal women: an observational study.BMC musculoskeletal disorders · 2018Observational
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundDespite increasing evidence of a common link between bone and heart health, the relationship between bone mineral density (BMD) and heart failure (HF) risk remains insufficiently studied. METHODS AND
resultsWe investigated whether BMD measured by dual-energy x-ray absorptiometry was associated with incident HF in an older cohort. Cox models were stratified by sex and interactions of BMD with race assessed. BMD was examined at the total hip and femoral neck separately, both continuously and by World Health Organization categories. Of 1250 participants, 442 (55% women) developed HF during the median follow-up of 10.5 years. In both black and nonblack women, neither total hip nor femoral neck BMD was significantly associated with HF; there was no significant interaction by race. In black and nonblack men, total hip, but not femoral neck, BMD was significantly associated with HF, with evidence of an interaction by race. In nonblack men, lower total hip BMD was associated with higher HF risk (hazard ratio, 1.13 [95% CI, 1.01-1.26] per 0.1 g/cm
conclusionsAmong older adults, lower total hip BMD was associated with higher HF risk in nonblack men but lower risk in black men, with no evidence of an association in women. Further research is needed to replicate these findings and to study potential underlying pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.