Evidence map›Paper›PMID 28288901›Full record

ArticleNeuroscience2017

Trigeminal brainstem modulation of persistent orbicularis oculi muscle activity in a rat model of dry eye.

Mostafeezur Rahman, Kazunari Shiozaki, Keiichiro Okamoto, Randall Thompson, David A Bereiter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Ion channels in dry eye disease.Indian journal of ophthalmology · 2023
    Review
  2. Article
  3. Electroacupuncture Suppresses CCI-Induced Neuropathic Pain through GABAA Receptors.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mostafeezur RahmanDepartment of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Moos Tower 18-186, 515 Delaware St. SE, Minneapolis, MN 55455, USA. Electronic address: mrahman@umn.edu.
Kazunari ShiozakiDepartment of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Moos Tower 18-186, 515 Delaware St. SE, Minneapolis, MN 55455, USA.
Keiichiro OkamotoDepartment of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Moos Tower 18-186, 515 Delaware St. SE, Minneapolis, MN 55455, USA.
Randall ThompsonDepartment of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Moos Tower 18-186, 515 Delaware St. SE, Minneapolis, MN 55455, USA.
David A BereiterDepartment of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Moos Tower 18-186, 515 Delaware St. SE, Minneapolis, MN 55455, USA.
University of Minnesota · US

Funding

Trigeminal-autonomic relations in ocular painR01EY021447 · NEI · UNIVERSITY OF MINNESOTA · PI BEREITER, DAVID A · 2011 to 2015
$1.5M
NEI NIH HHS R01 EY021447
6 · The paper itself

Abstract

Altered corneal reflex activity is a common feature of dry eye disease (DE). Trigeminal sensory nerves supply the ocular surface and terminate at the trigeminal interpolaris/caudalis (ViVc) transition and spinomedullary (VcC1) regions. Although both regions contribute to corneal reflexes, their role under dry eye conditions is not well defined. This study assessed the influence of local inhibitory and excitatory amino acid neurotransmission at the ViVc transition and VcC1 regions on hypertonic saline (HS) evoked orbicularis oculi muscle activity (OOemg) in urethane-anesthetized male rats after exorbital gland removal (DE). HS increased the magnitude of long-duration OOemg activity (OOemgL, >200ms) in DE compared to sham rats, while short-duration OOemg activity (OOemgS, <200ms) was similar for both groups. Inhibition of the ViVc transition by muscimol, a GABA

Indexed as

AnimalsBlinkingBrain StemDisease Models, AnimalDry Eye SyndromesMaleNeuronsN-MethylaspartateRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateSaline Solution, HypertonicSynaptic TransmissionTrigeminal NerveN-MethylaspartateReceptors, N-Methyl-D-AspartateSaline Solution, Hypertoniccorneal reflexdry eyeelectromyographyGABA receptorNMDA receptororbicularis oculi

Identifiers

PMID28288901
PMCPMC5408357
OpenAlexW2594765054

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.